Acrylamide
CASRN 79-06-1 | DTXSID5020027
- Toxicological Review (PDF) (459 pp, 4.84 M)
- IRIS Summary (PDF) (34 pp, 324 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(34 pp, 324 K)
Last Updated: 03/22/2010
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous | 2 x 10 -3 | Degenerative nerve changes |
HED
(BMDL):
0.053
mg/kg-day |
30 | Medium/High |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(34 pp, 324 K)
Last Updated: 03/22/2010
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous | 6 x 10 -3 | Degenerative nerve changes |
HEC
5
(BMDL):
0.18
mg/m3 |
30 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(34 pp, 324 K)
Last Updated: 03/22/2010
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Likely to be carcinogenic to humans | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- In accordance with the Guidelines for Carcinogen Risk Assessment U.S. EPA, 2005, acrylamide (AA) is characterized as "likely to be carcinogenic to humans."
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 324 K)
Oral Slope Factor:
5
x 10-1
per mg/kg-day
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMDL), summed risk.
Tumor site(s): Endocrine, Reproductive
Tumor type(s): thyroid tumors and tunica vaginalis mesotheliomas (Johnson et al., 1986)
Note: ADAF -- EPA has concluded that acrylamide is carcinogenic by a mutagenic mode of action. Application of age-dependent adjustment factors (ADAFs) to the oral slope factor is recommended in combination with appropriate exposure data when assessing risk associated with early-life exposure.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 324 K)
Inhalation Unit Risk:
1
x 10-4
per µg/m3
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMDL), summed risk.
Tumor site(s): Reproductive, Endocrine
Tumor type(s): thyroid tumors and tunica vaginalis mesotheliomas (Johnson et al., 1986)
Note: ADAF -- EPA has concluded that acrylamide is carcinogenic by a mutagenic mode of action. Application of age-dependent adjustment factors (ADAFs) to the inhalation unit risk is recommended in combination with appropriate exposure data when assessing risk associated with early-life exposure.
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