IRIS

Perfluorohexanoic Acid (PFHxA)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (70 pp, 480 K) Last Updated: 04/10/2023

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Developmental 5 x 10 -4
(Chronic)
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats BMD (HED): 4.8 x 10-2
mg/kg-day
100 Medium
Developmental 5 x 10 -4
(Subchronic)
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats BMD (HED): 4.8 x 10-2
mg/kg-day
100 Medium


Note: BMDL 5%RD.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (70 pp, 480 K) Last Updated: 04/10/2023
Information reviewed but value not estimated.

Note: NA

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (70 pp, 480 K) Last Updated: 04/10/2023
Information reviewed but value not estimated.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (70 pp, 480 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (70 pp, 480 K)

Not assessed under the IRIS Program.

Organ/System-Specific RfDs

System RfD (mg/kg-day) Basis PoD UF Confidence Notes
Developmental 5 x 10-4
(Chronic)
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats BMD (HED): 4.8 x 10-2
mg/kg-day
100 Medium BMDL 5%RD.
Hepatic 4 x 10-4
(Chronic)
Increased hepatocellular hypertrophy in adult male Crl:CD Sprague‑Dawley rats BMD (HED): 1.1 x 10-1
mg/kg-day
300 Medium BMDL 5%RD.
Hematologic 5 x 10-3
(Chronic)
Decreased red blood cells in adult female Crl:CD Sprague‑Dawley rats BMD (HED): 5.2 x 10-1
mg/kg-day
100 Medium BMDL 5%RD.
Developmental 5 x 10-4
(Subchronic)
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats BMD (HED): 4.8 x 10-2
mg/kg-day
100 Medium BMDL 5%RD.
Hepatic 1 x 10-3
(Subchronic)
Increased hepatocellular hypertrophy in adult rats BMD (HED): 1.1 x 10-1
mg/kg-day
100 Medium BMDL 5%RD.
Hematologic 8 x 10-4
(Subchronic)
Decreased red blood cells in adult female Crl:CD Sprague‑Dawley rats BMD (HED): 7.8 x 10-2
mg/kg-day
100 Low/Medium BMDL 5%RD.
Endocrine 1 x 10-3
(Subchronic)
Decreased total T4 in adult male Harlan Sprague-Dawley rats BMD (HED): 2.9 x 10-2
mg/kg-day
300 Medium BMDL 5%RD.

 

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