Perfluorohexanoic Acid (PFHxA)
CASRN 307-24-4 | DTXSID3031862
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (70 pp, 480 K) Last Updated: 04/10/2023
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Developmental |
5 x 10 -4
(Chronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8
x 10-2
mg/kg-day |
100 | Medium |
| Developmental |
5 x 10 -4
(Subchronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8
x 10-2
mg/kg-day |
100 | Medium |
Note: BMDL 5%RD.
Reference Concentration for Inhalation Exposure (RfC) (PDF) (70 pp, 480 K) Last Updated: 04/10/2023
Information reviewed but value not estimated.
Note: NA
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(70 pp, 480 K)
Last Updated: 04/10/2023
Information reviewed but value not estimated.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (70 pp, 480 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (70 pp, 480 K)
Not assessed under the IRIS Program.
Organ/System-Specific RfDs
| System | RfD (mg/m3) | Basis | PoD | UF | Confidence | Notes |
|---|---|---|---|---|---|---|
| Developmental |
5
x 10-4
(Chronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8 x 10-2 mg/kg-day |
100 | Medium | BMDL 5%RD. |
| Hepatic |
4
x 10-4
(Chronic) |
Increased hepatocellular hypertrophy in adult male Crl:CD Sprague‑Dawley rats |
BMD
(HED):
1.1 x 10-1 mg/kg-day |
300 | Medium | BMDL 5%RD. |
| Hematologic |
5
x 10-3
(Chronic) |
Decreased red blood cells in adult female Crl:CD Sprague‑Dawley rats |
BMD
(HED):
5.2 x 10-1 mg/kg-day |
100 | Medium | BMDL 5%RD. |
| Developmental |
5
x 10-4
(Subchronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8 x 10-2 mg/kg-day |
100 | Medium | BMDL 5%RD. |
| Hepatic |
1
x 10-3
(Subchronic) |
Increased hepatocellular hypertrophy in adult rats |
BMD
(HED):
1.1 x 10-1 mg/kg-day |
100 | Medium | BMDL 5%RD. |
| Hematologic |
8
x 10-4
(Subchronic) |
Decreased red blood cells in adult female Crl:CD Sprague‑Dawley rats |
BMD
(HED):
7.8 x 10-2 mg/kg-day |
100 | Low/Medium | BMDL 5%RD. |
| Endocrine |
1
x 10-3
(Subchronic) |
Decreased total T4 in adult male Harlan Sprague-Dawley rats |
BMD
(HED):
2.9 x 10-2 mg/kg-day |
300 | Medium | BMDL 5%RD. |
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Chemical Structure
