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Dichloromethane

CASRN 75-09-2 | DTXSID0020868

  • Toxicological Review (PDF)  (567  pp, 4.9 MB, about PDF)
  • IRIS Summary (PDF)  (44  pp, 329.1 KB, about PDF)
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IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Discussion Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA is releasing the draft report, Toxicological Review of Dichloromethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Background

The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane. Dichloromethane, also known as methylene chloride, is a colorless liquid. It is, or has been, used principally in paint strippers and removers, as a propellant in aerosols, in the manufacture of drugs, pharmaceuticals, film coatings, electronics, and polyurethane foam, as a metal cleaning solvent, and in the decaffeination process of coffee and tea.

History/Chronology
Date Description
Dec 2009 EPA hosted an interagency science consultation on the draft Toxicological Review of Dichloromethane.
Mar 2010 EPA released the external review draft for public comment. EPA also announced a public listening session on May 11, 2010. [Federal Register Mar 31, 2010]
Aug 2010 EPA announced the external peer review meeting to be held on September 23, 2010. [Federal Register Aug 17, 2010]
Nov 2010 EPA released the comments from the external review workshop.
Aug 2011 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Dichloromethane.
Nov 2011 EPA released the final Toxicological Review and IRIS Summary for Dichloromethane and the interagency review draft with interagency review comments.

Status

This assessment has been loaded into the IRIS Web site and Database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Toxicological Review of Dichloromethane (Interagency Science Discussion Draft) (PDF)  (584  pp, 4.6 MB, about PDF)
  • Dichloromethane Summary (Interagency Science Discussion Draft) (PDF)  (32  pp, 261.7 KB, about PDF)
  • EPA's Response & Interagency Science Discussion Comments (PDF)  (7  pp, 48.8 KB, about PDF)
  • 1. DOD DCM IASD Comments (PDF)  (3  pp, 37.1 KB, about PDF)
  • 2. NIEHS NTP DCM IASD Comments (PDF)  (1  pp, 39.1 KB, about PDF)
  • 3. OMB DCM IASD Comments (PDF)  (6  pp, 47.9 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft)
  • IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (External Review Draft)
  • IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Final Report)

Related Links

  • EPA Chemicals Dashboard - Dichloromethane
  • eChemPortal - Dichloromethane

Critical Effect Systems

Hepatic
Hepatic

Tumor Sites

Hepatic
Hepatic

Respiratory
Respiratory

Chemical Structure for
Dichloromethane

Dichloromethane

Synonyms

  • Aerothene MM
  • Chlorure de methylene
  • DCM
  • Dichlormethan, uvasol
  • Dichloromethane
  • Freon 30
  • Methane dichloride
  • Methane, dichloro-
  • Methylene bichloride
  • Methylene chloride
  • Methylene dichloride
  • Metylenu chlorek
  • NCI-C50102
  • Narkotil
  • R 30
  • Solaesthin
  • Solmethine
  • WLN: G1G
  • 1,1-Dichloromethane
  • 75-09-2
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Last updated on February 01, 2017
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