IRIS Critical Effect Search Results
Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the
RfD, RfC, oral slope factor, or inhalation unit risk.
Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with
organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see
Quick Check: Assessments in Development.
Search Filtered by: Critical Effect = "Musculoskeletal"
Number of records: 6
| Chemical Name | CASRN | Exposure Route | Critical Effect | RfD/RfC | RfD/RfC Value |
|---|---|---|---|---|---|
| Di(2-ethylhexyl)adipate | 103-23-1 | Oral | Changes in body weight and liver weight increased liver weight of male and female parents reduced ossification and slightly dilated ureters in fetuses reduced offspring weight gain, total litter weight, and litter size | RFD | 6 x 10 -1 mg/kg-day |
| Ethyl chloride | 75-00-3 | Inhalation | Delayed fetal ossification | RFC | 1 x 10 1 mg/m3 |
| Methyl ethyl ketone (MEK) | 78-93-3 | Inhalation | Developmental toxicity (skeletal variations) | RFC | 5 mg/m3 |
| Methyl isobutyl ketone (MIBK) | 108-10-1 | Inhalation | Reduced fetal body weight, skeletal variations, and increased fetal death in mice, and skeletal variations in rats. | RFC | 3 mg/m3 |
| Propargite | 2312-35-8 | Oral | Reduced body weight gain (maternal), increased resorption, reduced body weight (fetal), delayed ossification | RFD | 2 x 10 -2 mg/kg-day |
| Strontium | 7440-24-6 | Oral | Rachitic bone | RFD | 6 x 10 -1 mg/kg-day |
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