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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Tumor Site = "Reproductive"
Number of records: 12
Chemical Name CASRN Exposure Route WOE Characterization Tumor Type Toxicity Value
Acrylamide 79-06-1 Oral Likely to be carcinogenic to humans (2005 guidelines)
thyroid tumors and tunica vaginalis mesotheliomas
Acrylamide 79-06-1 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
thyroid tumors and tunica vaginalis mesotheliomas 1 x 10 -4 per µg/m3
Bromate 15541-45-4 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Carcinogenic potential cannot be determined (1996 guidelines)
Known/likely human carcinogen (1996 guidelines)
Testicular mesothelioma, renal tubular adenoma and carcinoma, and thyroid follicular cell adenoma and carcinoma 2 x 10 -5 per µg/L
Chloroprene 126-99-8 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma 3 x 10 -4 per µg/m3
1,2-Dibromoethane 106-93-4 Inhalation Likely to be carcinogenic to humans (1999 guidelines)
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas 3 x 10 -4 per µg/m3
central tendency estimate
1,2-Dibromoethane 106-93-4 Inhalation Likely to be carcinogenic to humans (1999 guidelines)
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas 6 x 10 -4 per µg/m3
95% upper bound
3,3'-Dichlorobenzidine 91-94-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Mammary adenocarcinoma 1.3 x 10 -5 per µg/L
2,4-/2,6-Dinitrotoluene mixture Various Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas 1.9 x 10 -5 per µg/L
1,4-Dioxane 123-91-1 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) 5 x 10 -6 per µg/m3
Ethylene oxide 75-21-8 Inhalation Carcinogenic to humans (2005 guidelines)
Lymphoid cancer, (female) breast cancer 3 x 10 -3 per µg/m3
Isophorone 78-59-1 Oral C (Possible human carcinogen) (1986 guidelines)
Preputial gland carcinoma 2.7 x 10 -8 per µg/L
1,2,3-Trichloropropane 96-18-4 Oral Likely to be carcinogenic to humans (2005 guidelines)
alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas