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IRIS Home | Critical Effect Search Results

Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Gastrointestinal"
Number of records: 13
Chemical Name CASRN Exposure Route Critical Effect RfD/RfC RfD/RfC Value
Benzaldehyde 100-52-7 Oral Forestomach lesions, kidney toxicity RFD 1 x 10 -1 mg/kg-day
Beryllium and compounds 7440-41-7 Oral Small intestinal lesions RFD 2 x 10 -3 mg/kg-day
Bromomethane 74-83-9 Oral Epithelial hyperplasia of the forestomach RFD 1.4 x 10 -3 mg/kg-day
Chloral hydrate 302-17-0 Oral CNS depression and GI irritation in humans RFD 1 x 10 -1 mg/kg-day
Chromium(VI) 18540-29-9 Oral Hyperplasia in small intesting of female mice (chronic exposure study). RFD 9 x 10 -4 mg/kg-day
Cypermethrin 52315-07-8 Oral G.I. tract disturbances RFD 1 x 10 -2 mg/kg-day
1,3-Dichloropropene 542-75-6 Oral Chronic irritation RFD 3 x 10 -2 mg/kg-day
Endothall 145-73-3 Oral Increased absolute and relative weights of stomach and small intestine RFD 2 x 10 -2 mg/kg-day
Fluorine (soluble fluoride) 7782-41-4 Oral Objectionable dental fluorosis, a cosmetic effect RFD 6 x 10 -2 mg/kg-day
Formaldehyde 50-00-0 Oral Reduced weight gain, histopathology in rats RFD 2 x 10 -1 mg/kg-day
Hexachlorocyclopentadiene (HCCPD) 77-47-4 Oral Chronic irritation RFD 6 x 10 -3 mg/kg-day
Hexachlorophene 70-30-4 Oral Swollen salivary glands, status spongiosis in brain and optic nerve RFD 3 x 10 -4 mg/kg-day
Propiconazole 60207-90-1 Oral Gastric mucosal irritation RFD 1.3 x 10 -2 mg/kg-day