IRIS Critical Effect Search Results

Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Gastrointestinal"
Number of records: 13

Chemical Name	CASRN	Exposure Route	Critical Effect	RfD/RfC	RfD/RfC Value
Benzaldehyde	100-52-7	Oral	Forestomach lesions, kidney toxicity	RFD	1 x 10 ^-1 mg/kg-day
Beryllium and compounds	7440-41-7	Oral	Small intestinal lesions	RFD	2 x 10 ^-3 mg/kg-day
Bromomethane	74-83-9	Oral	Epithelial hyperplasia of the forestomach	RFD	1.4 x 10 ^-3 mg/kg-day
Chloral hydrate	302-17-0	Oral	CNS depression and GI irritation in humans	RFD	1 x 10 ^-1 mg/kg-day
Chromium(VI)	18540-29-9	Oral	Hyperplasia in small intesting of female mice (chronic exposure study).	RFD	9 x 10 ^-4 mg/kg-day
Cypermethrin	52315-07-8	Oral	G.I. tract disturbances	RFD	1 x 10 ^-2 mg/kg-day
1,3-Dichloropropene	542-75-6	Oral	Chronic irritation	RFD	3 x 10 ^-2 mg/kg-day
Endothall	145-73-3	Oral	Increased absolute and relative weights of stomach and small intestine	RFD	2 x 10 ^-2 mg/kg-day
Fluorine (soluble fluoride)	7782-41-4	Oral	Objectionable dental fluorosis, a cosmetic effect	RFD	6 x 10 ^-2 mg/kg-day
Formaldehyde	50-00-0	Oral	Reduced weight gain, histopathology in rats	RFD	2 x 10 ^-1 mg/kg-day
Hexachlorocyclopentadiene (HCCPD)	77-47-4	Oral	Chronic irritation	RFD	6 x 10 ^-3 mg/kg-day
Hexachlorophene	70-30-4	Oral	Swollen salivary glands, status spongiosis in brain and optic nerve	RFD	3 x 10 ^-4 mg/kg-day
Propiconazole	60207-90-1	Oral	Gastric mucosal irritation	RFD	1.3 x 10 ^-2 mg/kg-day