IRIS
IRIS Home | Tumor Site Search Results
Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the
RfD, RfC, oral slope factor, or inhalation unit risk.
Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with
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Quick Check: Assessments in Development.
Search Filtered by: Tumor Site = "Gastrointestinal"
Number of records: 15
| Chemical Name | CASRN | Exposure Route | WOE Characterization | Tumor Type | Toxicity Value |
|---|---|---|---|---|---|
| Acrylonitrile | 107-13-1 | Oral |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) |
Brain and spinal cord astrocytomas, Zymbal gland carcinomas and stomach papillomas/ carcinomas | 1.5 x 10 -5 per µg/L |
| Benzo[a]pyrene (BaP) | 50-32-8 | Oral |
Carcinogenic to humans (2005 guidelines) |
forestomach, esophagus, tongue, and larynx tumors | |
| Benzo[a]pyrene (BaP) | 50-32-8 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Squamous cell neoplasia in the larynx, pharynx, trachea, nasal cavity, esophagus, and forestomach. | 6 x 10 -4 per µg/m3 |
| Bromoform | 75-25-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic lesions in the large intestine | 1.1 x 10 -6 per µg/m3 |
| Bromoform | 75-25-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic lesions in the large intestine | 2.3 x 10 -7 per µg/L |
| Chloroprene | 126-99-8 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma | 3 x 10 -4 per µg/m3 |
| 1,2-Dibromoethane | 106-93-4 | Oral |
Likely to be carcinogenic to humans (1999 guidelines) |
Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas | |
| 1,2-Dibromoethane | 106-93-4 | Oral |
Likely to be carcinogenic to humans (1999 guidelines) |
Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas |
6 x 10 -5 per µg/L 95% upper bound |
| Dichlorvos | 62-73-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Forestomach tumors, pancreatic acinar adenoma, leukemia | 8.3 x 10 -6 per µg/L |
| 1,4-Dioxane | 123-91-1 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) | 5 x 10 -6 per µg/m3 |
| Epichlorohydrin | 106-89-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Papillomas and carcinomas of the forestomach | 2.8 x 10 -7 per µg/L |
| N-Nitroso-di-n-butylamine | 924-16-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Bladder and esophagus tumors | 1.6 x 10 -4 per µg/L |
| N-Nitroso-di-n-butylamine | 924-16-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Bladder and esophagus tumors | 1.6 x 10 -3 per µg/m3 |
| Propylene oxide | 75-56-9 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Forestomach, squamous cell carcinoma | 6.8 x 10 -6 per µg/L |
| 1,2,3-Trichloropropane | 96-18-4 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas |