IRIS Critical Effect Search Results
Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the
RfD, RfC, oral slope factor, or inhalation unit risk.
Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with
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Search Filtered by: Critical Effect = "Reproductive"
Number of records: 41
| Chemical Name | CASRN | Exposure Route | Critical Effect | RfD/RfC | RfD/RfC Value |
|---|---|---|---|---|---|
| Acetochlor | 34256-82-1 | Oral | Salivation, increased ALT and ornithine carbamyl transferase; significant increases in triglyceride and decreased blood glucose levels; histopathological changes in kidneys and testes of males | RFD | 2 x 10 -2 mg/kg-day |
| Asulam | 3337-71-1 | Oral | Lower ovarian weight, lower liver/body weight | RFD | 5 x 10 -2 mg/kg-day |
| Benzo[a]pyrene (BaP) | 50-32-8 | Inhalation | Reduced ovulation rate and ovary weight | RFC | 3 x 10 -6 mg/m3 |
| Benzo[a]pyrene (BaP) | 50-32-8 | Oral | Decreased ovarian follicles and ovary weight | RFD | 4 x 10 -4 mg/kg-day |
| Bidrin | 141-66-2 | Oral | Decreased pup survival | RFD | 1 x 10 -4 mg/kg-day |
| 1,3-Butadiene | 106-99-0 | Inhalation | Ovarian atrophy | RFC | 2 x 10 -3 mg/m3 |
| Calcium cyanide | 592-01-8 | Oral | Decreased cauda epididymis weight in male F344/N rats. The RfD for cyanide, free is presented in section I.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. | RFD | 1 x 10 -3 mg/kg-day |
| Carbofuran | 1563-66-2 | Oral | RBC and plasma cholinesterase inhibition, and testicular and uterine effects | RFD | 5 x 10 -3 mg/kg-day |
| 2-Chlorophenol | 95-57-8 | Oral | Reproductive effects | RFD | 5 x 10 -3 mg/kg-day |
| Cyanide, free | 57-12-5 | Oral | Decreased cauda epididymis weight in male F344/N rats. The RfD for cyanide, free is presented in section 1.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. | RFD | 6.3 x 10 -4 mg/kg-day |
| Cyclohexylamine | 108-91-8 | Oral | Testicular damage | RFD | 2 x 10 -1 mg/kg-day |
| 1,2-Dibromo-3-chloropropane (DBCP) | 96-12-8 | Inhalation | Testicular effects | RFC | 2 x 10 -4 mg/m3 |
| 1,2-Dibromoethane | 106-93-4 | Oral | Testicular atrophy, liver peliosis, and adrenal cortical degeneration | RFD |