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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Reproductive"
Number of records: 39
Chemical Name CASRN Exposure Route Critical Effect RfD/RfC RfD/RfC Value
Acetochlor 34256-82-1 Oral Salivation, increased ALT and ornithine carbamyl transferase; significant increases in triglyceride and decreased blood glucose levels; histopathological changes in kidneys and testes of males RFD 2 x 10 -2 mg/kg-day
Asulam 3337-71-1 Oral Lower ovarian weight, lower liver/body weight RFD 5 x 10 -2 mg/kg-day
Benzo[a]pyrene (BaP) 50-32-8 Oral Decreased ovarian follicles and ovary weight RFD 4 x 10 -4 mg/kg-day
Benzo[a]pyrene (BaP) 50-32-8 Inhalation Reduced ovulation rate and ovary weight RFC 3 x 10 -6 mg/m3
Bidrin 141-66-2 Oral Decreased pup survival RFD 1 x 10 -4 mg/kg-day
1,3-Butadiene 106-99-0 Inhalation Ovarian atrophy RFC 2 x 10 -3 mg/m3
Calcium cyanide 592-01-8 Oral Decreased cauda epididymis weight in male F344/N rats. The RfD for cyanide, free is presented in section I.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. RFD 1 x 10 -3 mg/kg-day
Carbofuran 1563-66-2 Oral RBC and plasma cholinesterase inhibition, and testicular and uterine effects RFD 5 x 10 -3 mg/kg-day
2-Chlorophenol 95-57-8 Oral Reproductive effects RFD 5 x 10 -3 mg/kg-day
Cyanide, free 57-12-5 Oral Decreased cauda epididymis weight in male F344/N rats. The RfD for cyanide, free is presented in section 1.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. RFD 6.3 x 10 -4 mg/kg-day
Cyclohexylamine 108-91-8 Oral Testicular damage RFD 2 x 10 -1 mg/kg-day
1,2-Dibromo-3-chloropropane (DBCP) 96-12-8 Inhalation Testicular effects RFC 2 x 10 -4 mg/m3
1,2-Dibromoethane 106-93-4 Oral Testicular atrophy, liver peliosis, and adrenal cortical degeneration RFD 9 x 10 -3 mg/kg-day
Dichloroacetic acid 79-43-6 Oral Lesions observed in the testes, cerebrum, cerebellum, and liver. RFD 4 x 10 -3 mg/kg-day
2-Ethoxyethanol 110-80-5 Inhalation Decreased testis weight, seminiferous tubule degeneration and decreased hemoglobin RFC 2 x 10 -1 mg/m3
Fluridone 59756-60-4 Oral Glomerulonephritis, atrophic testes, eye keratitis decreased body weight and organ weights RFD 8 x 10 -2 mg/kg-day
Flutolanil 66332-96-5 Oral Decreased body weight and body weight gains in both doses increased liver weights at high dose RFD 6 x 10 -2 mg/kg-day
Fosetyl-al 39148-24-8 Oral Slight testicular degeneration RFD 3 mg/kg-day
Haloxyfop-methyl 69806-40-2 Oral Reduced relative kidney weights in F0, F1, and F2b adults; reduced fertility in the F1/F2b generation RFD 5 x 10 -5 mg/kg-day
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) 121-82-4 Oral Suppurative prostatitis in F344 rats RFD 8 x 10 -4 mg/kg-day
Hydrogen Cyanide and Cyanide Salts Various Oral Decreased cauda epididymis weight in male F344/N rats RFD 6 x 10 -4 mg/kg-day
Iprodione 36734-19-7 Oral Increased RBC Heinz bodies; decreased prostate weight RFD 4 x 10 -2 mg/kg-day
2-Methoxyethanol 109-86-4 Inhalation Testicular effects RFC 2 x 10 -2 mg/m3
4-(2-Methyl-4-chlorophenoxy) butyric acid (MCPB) 94-81-5 Oral Male reproductive toxicity and other effects (including decreased body weight gain), increased liver and kidney weights RFD 1 x 10 -2 mg/kg-day
Metolachlor 51218-45-2 Oral Decreased body weight gain, decreased pup weight and parental food consumption RFD 1.5 x 10 -1 mg/kg-day
Molinate 2212-67-1 Oral Reproductive toxicity RFD 2 x 10 -3 mg/kg-day
Napropamide 15299-99-7 Oral Decreased body weight gain in parental animals and pups RFD 1 x 10 -1 mg/kg-day
Potassium cyanide 151-50-8 Oral Decreased cauda epididymis weight in male F344/N rats. The RfD for potassium cyanide is presented in section I.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. RFD 2 x 10 -3 mg/kg-day
Potassium silver cyanide 506-61-6 Oral Decreased cauda epididymis weight in male F344/N rats. The RfD for potassium cyanide is presented in section I.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. RFD 5 x 10 -3 mg/kg-day
Resmethrin 10453-86-8 Oral Reproductive toxicity RFD 3 x 10 -2 mg/kg-day
Sodium cyanide 143-33-9 Oral Decreased cauda epididymis weight in male F344/N rats. The RfD for potassium cyanide is presented in section I.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. RFD 1 x 10 -3 mg/kg-day
Sodium fluoroacetate 62-74-8 Oral Increased heart weight in females and males; decreased testis weight and altered spermatogenesis in males. RFD 2 x 10 -5 mg/kg-day
Systhane 88671-89-0 Oral Testicular atrophy RFD 2.5 x 10 -2 mg/kg-day
2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 Oral Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates RFD 7 x 10 -10 mg/kg-day
2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 Oral Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates RFD 7 x 10 -10 mg/kg-day
1,1,1,2-Tetrafluoroethane 811-97-2 Inhalation Leydig cell hyperplasia RFC 8 x 10 1 mg/m3
Thiophanate-methyl 23564-05-8 Oral Decreased body weight, decreased spermatogenesis, and histological evidence of hyperthyroidism RFD 8 x 10 -2 mg/kg-day
Tridiphane 58138-08-2 Oral Decreased fertility index and depressed body weight of dams RFD 3 x 10 -3 mg/kg-day
White phosphorus 7723-14-0 Oral Parturition mortality; forelimb hair loss RFD 2 x 10 -5 mg/kg-day