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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Immune"
Number of records: 29
Chemical Name CASRN Exposure Route Critical Effect RfD/RfC RfD/RfC Value
Aroclor 1254 11097-69-1 Oral Ocular exudate, inflamed and prominent Meibomian glands, distorted growth of finger and toe nails; decreased antibody (IgG and IgM) response to sheep erythrocytes RFD 2 x 10 -5 mg/kg-day
Arsine 7784-42-1 Inhalation Increased hemolysis, abnormal RBC morphology, and increased spleen weight RFC 5 x 10 -5 mg/m3
Benzene 71-43-2 Inhalation Decreased lymphocyte count RFC 3 x 10 -2 mg/m3
Benzene 71-43-2 Oral Decreased lymphocyte count RFD 4 x 10 -3 mg/kg-day
Benzo[a]pyrene (BaP) 50-32-8 Oral Decreased thymus weight and serum IgM RFD 2 x 10 -3 mg/kg-day
Beryllium and compounds 7440-41-7 Inhalation Beryllium sensitization and progression to CBD RFC 2 x 10 -5 mg/m3
p-Chloroaniline 106-47-8 Oral Nonneoplastic lesions of splenic capsule RFD 4 x 10 -3 mg/kg-day
Chloroprene 126-99-8 Inhalation Increase in incidence of olfactory atrophy, alveolar hyperplasia, and splenic hematopoietic proliferation in male F344/N rats, female F344/N rats, and female B6C3F1 mice, respectively RFC 2 x 10 -2 mg/m3
Chlorpropham 101-21-3 Oral Kidney, spleen, liver, and bone marrow toxicity RFD 2 x 10 -1 mg/kg-day
trans-1,2-Dichloroethylene 156-60-5 Oral Decrease in number of antibody forming cells (AFCs) against sheep red blood cells (sRBCs) in male mice RFD 2 x 10 -2 mg/kg-day
2,4-Dichlorophenol 120-83-2 Oral Decreased delayed hypersensitivity response RFD 3 x 10 -3 mg/kg-day
N-N-Dimethylaniline 121-69-7 Oral Splenomegaly, increased splenic hemosiderosis and hematopoiesis RFD 2 x 10 -3 mg/kg-day
3,4-Dimethylphenol 95-65-8 Oral Changes in blood pressure and body weight histopathological changes in liver, kidney and spleen RFD 1 x 10 -3 mg/kg-day
2,6-Dimethylphenol 576-26-1 Oral Body weight changes and histopathological changes of internal organs (liver, spleen and kidneys) RFD 6 x 10 -4 mg/kg-day
m-Dinitrobenzene 99-65-0 Oral Increased splenic weight RFD 1 x 10 -4 mg/kg-day
Imazaquin 81335-37-7 Oral Decreased body weight gain, skeletal myopathy, slight anemia, bone marrow hyperplasia, elevated serum SGOT, SGPT, CPK RFD 2.5 x 10 -1 mg/kg-day
Mercuric chloride (HgCl2) 7487-94-7 Oral Autoimmune effects (autoimmune glomerulonephritis) RFD 3 x 10 -4 mg/kg-day
Methomyl 16752-77-5 Oral Kidney and spleen pathology RFD 2.5 x 10 -2 mg/kg-day
Perfluorodecanoic Acid (PFDA) 335-76-2 Oral Decreased serum antibody concentrations for tetanus and diphtheria in children; Decreased birth weight in male and female children RFD 2 x 10 -9 mg/kg-day
Perfluorodecanoic Acid (PFDA) 335-76-2 Oral Decreased serum antibody concentrations for tetanus and diphtheria in children; Decreased birth weight in male and female children RFD 2 x 10 -9 mg/kg-day
Prometryn 7287-19-6 Oral Liver and kidney degeneration and bone marrow atrophy RFD 4 x 10 -3 mg/kg-day
Propanil 709-98-8 Oral Increased relative spleen weight in females RFD 5 x 10 -3 mg/kg-day
Propham 122-42-9 Oral Increase in male spleen weight and ChE depression in females RFD 2 x 10 -2 mg/kg-day
Tetraethyl lead 78-00-2 Oral Histopathology of liver and thymus RFD 1 x 10 -7 mg/kg-day
Tributyltin oxide (TBTO) 56-35-9 Oral Immunosuppression RFD 3 x 10 -4 mg/kg-day
1,1,2-Trichloroethane 79-00-5 Oral Clinical serum chemistry (effects on erythrocytes and depressed humoral immune status) RFD 4 x 10 -3 mg/kg-day
Trichloroethylene 79-01-6 Inhalation (See Note) RFC 2 x 10 -3 mg/m3
Trichloroethylene 79-01-6 Oral (See Note) RFD 5 x 10 -4 mg/kg-day
Zinc and Compounds 7440-66-6 Oral Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers RFD 3 x 10 -1 mg/kg-day