IRIS Tumor Site Search Results
Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the
RfD, RfC, oral slope factor, or inhalation unit risk.
Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with
organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see
Quick Check: Assessments in Development.
Search Filtered by: Tumor Site = "Urinary"
Number of records: 19
| Chemical Name | CASRN | Exposure Route | WOE Characterization | Tumor Type | Toxicity Value |
|---|---|---|---|---|---|
| Arsenic, Inorganic | 7440-38-2 | Oral |
Carcinogenic to humans (2005 guidelines) |
Bladder Cancer and Lung Cancer | |
| Benzidine | 92-87-5 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Bladder tumors | 6.7 x 10 -2 per µg/m3 |
| Benzidine | 92-87-5 | Oral |
A (Human carcinogen) (1986 guidelines) |
Bladder tumors | 6.7 x 10 -3 per µg/L |
| Bromate | 15541-45-4 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Carcinogenic potential cannot be determined (1996 guidelines) Known/likely human carcinogen (1996 guidelines) |
Testicular mesothelioma, renal tubular adenoma and carcinoma, and thyroid follicular cell adenoma and carcinoma | 2 x 10 -5 per µg/L |
| Bromodichloromethane | 75-27-4 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Kidney (tubular cell adenoma and tubular cell adenocarcinoma) | 1.8 x 10 -6 per µg/L |
| 1,3-Dichloropropene | 542-75-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Urinary bladder carcinoma | 3 x 10 -6 per µg/L |
| 1,4-Dioxane | 123-91-1 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) | 5 x 10 -6 per µg/m3 |
| Hexachlorobutadiene | 87-68-3 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Renal tubular adenomas and adenocarcinomas | 2.2 x 10 -5 per µg/m3 |
| Hexachlorobutadiene | 87-68-3 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Renal tubular adenomas and adenocarcinomas | 2.2 x 10 -6 per µg/L |
| Hexachloroethane | 67-72-1 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Renal adenomas and carcinomas (combined) | 1 x 10 -6 per µg/L |
| Nitrobenzene | 98-95-3 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomas | 4 x 10 -5 per µg/m3 |
| N-Nitroso-di-n-butylamine | 924-16-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Bladder and esophagus tumors | 1.6 x 10 -4 per µg/L |
| N-Nitroso-di-n-butylamine | 924-16-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Bladder and esophagus tumors | 1.6 x 10 -3 per µg/m3 |
| N-Nitrosodiphenylamine | 86-30-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Transitional cell carcinoma of the bladder | 1.4 x 10 -7 per µg/L |
| Trichloroethylene | 79-01-6 | Oral |
Carcinogenic to humans (2005 guidelines) |
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors | |
| Trichloroethylene | 79-01-6 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors | 4.8 x 10 -6 per µg/m3 |
| Trifluralin | 1582-09-8 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Combined renal pelvis carcinomas, urinary bladder papillomas and/or thyroid adenomas and carcinomas | 2.2 x 10 -7 per µg/L |
| 2,4,6-Trinitrotoluene (TNT) | 118-96-7 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Urinary bladder, transitional cell papilloma and transitional squamous cell carcinomas | 9.0 x 10 -7 per µg/L |
| tert-Butyl Alcohol (tBA) | 75-65-0 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Renal adenomas and carcinomas, thyroid adenomas |
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