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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Endocrine"
Number of records: 29
Chemical Name CASRN Exposure Route Critical Effect RfD/RfC RfD/RfC Value
Apollo 74115-24-5 Oral Liver effects; organ weight changes RFD 1.3 x 10 -2 mg/kg-day
Chlorine cyanide 506-77-4 Oral Weight loss, thyroid effects, and myelin degeneration RFD 5 x 10 -2 mg/kg-day
Chlorodifluoromethane 75-45-6 Inhalation Increased kidney, adrenal and pituitary weights RFC 5 x 10 1 mg/m3
Cumene 98-82-8 Inhalation Increased kidney weights in female rats and adrenal weights in male and female rats RFC 4 x 10 -1 mg/m3
Cyanogen bromide 506-68-3 Oral Weight loss, thyroid effects and myelin degeneration RFD 9 x 10 -2 mg/kg-day
Dacthal 1861-32-1 Oral Effects on the lungs, liver, kidney, thyroid and thyroid hormones in males and females and eyes of females RFD 1 x 10 -2 mg/kg-day
1,2-Dibromoethane 106-93-4 Oral Testicular atrophy, liver peliosis, and adrenal cortical degeneration RFD 9 x 10 -3 mg/kg-day
Dodine 2439-10-3 Oral Thyroid toxicity RFD 4 x 10 -3 mg/kg-day
Ethylene thiourea (ETU) 96-45-7 Oral Increased incidence of thyroid hyperplasia RFD 8 x 10 -5 mg/kg-day
Glycidaldehyde 765-34-4 Oral Weight gain retardation, enlarged adrenals, hydropic renal pelvis and hematopoietic effects RFD 4 x 10 -4 mg/kg-day
Hydrogen Cyanide and Cyanide Salts Various Inhalation Thyroid enlargement and altered iodide uptake RFC 8 x 10 -4 mg/m3
Maneb 12427-38-2 Oral Increased thyroid weight RFD 5 x 10 -3 mg/kg-day
Mirex 2385-85-5 Oral Liver cytomegaly, fatty metamorphosis, angiectasis; thyroid cystic follicles RFD 2 x 10 -4 mg/kg-day
Norflurazon 27314-13-2 Oral Liver and thyroid effects RFD 4 x 10 -2 mg/kg-day
Oryzalin 19044-88-3 Oral Increases in serum cholesterol, alkaline phosphatase, and relative liver and kidney weights, and decreases in alanine transaminase and adrenal weights RFD 5 x 10 -2 mg/kg-day
Perchlorate (ClO4) and Perchlorate Salts 7790-98-9 Oral Radioactive iodide uptake inhibition (RAIU) in the thyroid RFD 7 x 10 -4 mg/kg-day
Perfluorobutanoic Acid (PFBA) 375-22-4 Oral Decreased total T4 RFD 1 x 10 -2 mg/kg-day
Perfluorobutanoic Acid (PFBA) 375-22-4 Oral Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) RFD 1 x 10 -3 mg/kg-day
Perfluorohexanoic Acid (PFHxA) 307-24-4 Oral Decreased total T4 in adult male Harlan Sprague-Dawley rats RFD 1 x 10 -3 mg/kg-day
Savey 78587-05-0 Oral Hypertrophy of adrenal cortex (both sexes) hematologic effects (males) RFD 2.5 x 10 -2 mg/kg-day
Silver cyanide 506-64-9 Oral Weight loss, thyroid effects, and myelin degeneration RFD 1 x 10 -1 mg/kg-day
Terbacil 5902-51-2 Oral Increase in thyroid/body weight ratio; slight increase in liver weights; elevated alkaline phosphatase RFD 1.3 x 10 -2 mg/kg-day
2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 Oral Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates RFD 7 x 10 -10 mg/kg-day
Thiophanate-methyl 23564-05-8 Oral Decreased body weight, decreased spermatogenesis, and histological evidence of hyperthyroidism RFD 8 x 10 -2 mg/kg-day
1,2,4-Trichlorobenzene 120-82-1 Oral Increased adrenal weights; vacuolization of zona fasciculata in the cortex RFD 1 x 10 -2 mg/kg-day
1,1,2-Trichloropropane 598-77-6 Oral Mild lesions in liver, kidney and thyroid RFD 5 x 10 -3 mg/kg-day
Vinclozolin 50471-44-8 Oral Organ weight changes (adrenal and kidney) RFD 2.5 x 10 -2 mg/kg-day
Zinc cyanide 557-21-1 Oral Weight loss, thyroid effects, and myelin degeneration RFD 5 x 10 -2 mg/kg-day
Zineb 12122-67-7 Oral Thyroid hyperplasia RFD 5 x 10 -2 mg/kg-day