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Search Filtered by: Critical Effect = "Endocrine"
Number of records: 29
| Chemical Name | CASRN | Exposure Route | Critical Effect | RfD/RfC | RfD/RfC Value |
|---|---|---|---|---|---|
| Apollo | 74115-24-5 | Oral | Liver effects; organ weight changes | RFD | 1.3 x 10 -2 mg/kg-day |
| Chlorine cyanide | 506-77-4 | Oral | Weight loss, thyroid effects, and myelin degeneration | RFD | 5 x 10 -2 mg/kg-day |
| Chlorodifluoromethane | 75-45-6 | Inhalation | Increased kidney, adrenal and pituitary weights | RFC | 5 x 10 1 mg/m3 |
| Cumene | 98-82-8 | Inhalation | Increased kidney weights in female rats and adrenal weights in male and female rats | RFC | 4 x 10 -1 mg/m3 |
| Cyanogen bromide | 506-68-3 | Oral | Weight loss, thyroid effects and myelin degeneration | RFD | 9 x 10 -2 mg/kg-day |
| Dacthal | 1861-32-1 | Oral | Effects on the lungs, liver, kidney, thyroid and thyroid hormones in males and females and eyes of females | RFD | 1 x 10 -2 mg/kg-day |
| 1,2-Dibromoethane | 106-93-4 | Oral | Testicular atrophy, liver peliosis, and adrenal cortical degeneration | RFD | 9 x 10 -3 mg/kg-day |
| Dodine | 2439-10-3 | Oral | Thyroid toxicity | RFD | 4 x 10 -3 mg/kg-day |
| Ethylene thiourea (ETU) | 96-45-7 | Oral | Increased incidence of thyroid hyperplasia | RFD | 8 x 10 -5 mg/kg-day |
| Glycidaldehyde | 765-34-4 | Oral | Weight gain retardation, enlarged adrenals, hydropic renal pelvis and hematopoietic effects | RFD | 4 x 10 -4 mg/kg-day |
| Hydrogen Cyanide and Cyanide Salts | Various | Inhalation | Thyroid enlargement and altered iodide uptake | RFC | 8 x 10 -4 mg/m3 |
| Maneb | 12427-38-2 | Oral | Increased thyroid weight | RFD | 5 x 10 -3 mg/kg-day |
| Mirex | 2385-85-5 | Oral | Liver cytomegaly, fatty metamorphosis, angiectasis; thyroid cystic follicles | RFD | 2 x 10 -4 mg/kg-day |
| Norflurazon | 27314-13-2 | Oral | Liver and thyroid effects | RFD | 4 x 10 -2 mg/kg-day |
| Oryzalin | 19044-88-3 | Oral | Increases in serum cholesterol, alkaline phosphatase, and relative liver and kidney weights, and decreases in alanine transaminase and adrenal weights | RFD | 5 x 10 -2 mg/kg-day |
| Perchlorate (ClO4) and Perchlorate Salts | 7790-98-9 | Oral | Radioactive iodide uptake inhibition (RAIU) in the thyroid | RFD | 7 x 10 -4 mg/kg-day |
| Perfluorobutanoic Acid (PFBA) | 375-22-4 | Oral | Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) | RFD | 1 x 10 -3 mg/kg-day |
| Perfluorobutanoic Acid (PFBA) | 375-22-4 | Oral | Decreased total T4 | RFD | 1 x 10 -2 mg/kg-day |
| Perfluorohexanoic Acid (PFHxA) | 307-24-4 | Oral | Decreased total T4 in adult male Harlan Sprague-Dawley rats | RFD | 1 x 10 -3 mg/kg-day |
| Savey | 78587-05-0 | Oral | Hypertrophy of adrenal cortex (both sexes) hematologic effects (males) | RFD | 2.5 x 10 -2 mg/kg-day |
| Silver cyanide | 506-64-9 | Oral | Weight loss, thyroid effects, and myelin degeneration | RFD | 1 x 10 -1 mg/kg-day |
| Terbacil | 5902-51-2 | Oral | Increase in thyroid/body weight ratio; slight increase in liver weights; elevated alkaline phosphatase | RFD | 1.3 x 10 -2 mg/kg-day |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin | 1746-01-6 | Oral | Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates | RFD | 7 x 10 -10 mg/kg-day |
| Thiophanate-methyl | 23564-05-8 | Oral | Decreased body weight, decreased spermatogenesis, and histological evidence of hyperthyroidism | RFD | 8 x 10 -2 mg/kg-day |
| 1,2,4-Trichlorobenzene | 120-82-1 | Oral | Increased adrenal weights; vacuolization of zona fasciculata in the cortex | RFD | 1 x 10 -2 mg/kg-day |
| 1,1,2-Trichloropropane | 598-77-6 | Oral | Mild lesions in liver, kidney and thyroid | RFD | 5 x 10 -3 mg/kg-day |
| Vinclozolin | 50471-44-8 | Oral | Organ weight changes (adrenal and kidney) | RFD | 2.5 x 10 -2 mg/kg-day |
| Zinc cyanide | 557-21-1 | Oral | Weight loss, thyroid effects, and myelin degeneration | RFD | 5 x 10 -2 mg/kg-day |
| Zineb | 12122-67-7 | Oral | Thyroid hyperplasia | RFD | 5 x 10 -2 mg/kg-day |