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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Tumor Site = "Respiratory"
Number of records: 26
Chemical Name CASRN Exposure Route WOE Characterization Tumor Type Toxicity Value
Acetaldehyde 75-07-0 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal squamous cell carcinoma or adenocarcinoma 2.2 x 10 -6 per µg/m3
Acrylonitrile 107-13-1 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Respiratory cancer 6.8 x 10 -5 per µg/m3
Arsenic, Inorganic 7440-38-2 Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer 4.3 x 10 -3 per µg/m3
Asbestos 1332-21-4 Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer and mesothelioma 2.3 x 10 -1 per f/mL
Benzo[a]pyrene (BaP) 50-32-8 Inhalation Carcinogenic to humans (2005 guidelines)
Squamous cell neoplasia in the larynx, pharynx, trachea, nasal cavity, esophagus, and forestomach. 6 x 10 -4 per µg/m3
Benzotrichloride 98-07-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Lung, adenocarcinoma 3.6 x 10 -4 per µg/L
Beryllium and compounds 7440-41-7 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Carcinogenic potential cannot be determined (1996 guidelines)
Known/likely human carcinogen (1996 guidelines)
Lung cancer 2.4 x 10 -3 per µg/m3
Bis(chloromethyl)ether (BCME) 542-88-1 Oral A (Human carcinogen) (1986 guidelines)
Respiratory tract tumors 6.2 x 10 -3 per µg/L
Bis(chloromethyl)ether (BCME) 542-88-1 Inhalation A (Human carcinogen) (1986 guidelines)
Respiratory tract tumors 6.2 x 10 -2 per µg/m3
Cadmium 7440-43-9 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Lung, trachea, bronchus cancer deaths 1.8 x 10 -3 per µg/m3
Chloroprene 126-99-8 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma 3 x 10 -4 per µg/m3
Chromium(VI) 18540-29-9 Inhalation A (Human carcinogen) (1986 guidelines)
Carcinogenic potential cannot be determined (1996 guidelines)
D (Not classifiable as to human carcinogenicity) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Lung cancer 1.2 x 10 -2 per µg/m3
Coke oven emissions Inhalation A (Human carcinogen) (1986 guidelines)
Respiratory cancer 6.2 x 10 -4 per µg/m3
1,2-Dibromoethane 106-93-4 Inhalation Likely to be carcinogenic to humans (1999 guidelines)
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas 6 x 10 -4 per µg/m3
95% upper bound
1,2-Dibromoethane 106-93-4 Inhalation Likely to be carcinogenic to humans (1999 guidelines)
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas 3 x 10 -4 per µg/m3
central tendency estimate
Dichloromethane 75-09-2 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas 1 x 10 -8 per µg/m3
1,3-Dichloropropene 542-75-6 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Bronchioalveolar adenoma 4 x 10 -6 per µg/m3
1,4-Dioxane 123-91-1 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) 5 x 10 -6 per µg/m3
Epichlorohydrin 106-89-8 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal cavity tumors 1.2 x 10 -6 per µg/m3
Formaldehyde 50-00-0 Inhalation B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines)
Squamous cell carcinoma 1.3 x 10 -5 per µg/m3
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) 121-82-4 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas)
Hydrazine/Hydrazine sulfate 302-01-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal cavity adenoma or adenocarcinoma 4.9 x 10 -3 per µg/m3
Libby Amphibole Asbestos 1318-09-8 Inhalation Carcinogenic to humans (2005 guidelines)
Cancer mortality from lung cancer and mesothelioma 1.7 x 10 -1 per fiber/cc
Nickel refinery dust Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer 2.4 x 10 -4 per µg/m3
Nickel subsulfide 12035-72-2 Inhalation A (Human carcinogen) (1986 guidelines)
Lung cancer 4.8 x 10 -4 per µg/m3
Propylene oxide 75-56-9 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Nasal cavity hemangioma or hemangiosarcoma 3.7 x 10 -6 per µg/m3