IRIS
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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the
RfD, RfC, oral slope factor, or inhalation unit risk.
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Search Filtered by: Tumor Site = "Respiratory"
Number of records: 26
| Chemical Name | CASRN | Exposure Route | WOE Characterization | Tumor Type | Toxicity Value |
|---|---|---|---|---|---|
| Acetaldehyde | 75-07-0 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal squamous cell carcinoma or adenocarcinoma | 2.2 x 10 -6 per µg/m3 |
| Acrylonitrile | 107-13-1 | Inhalation |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) |
Respiratory cancer | 6.8 x 10 -5 per µg/m3 |
| Arsenic, Inorganic | 7440-38-2 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer | 4.3 x 10 -3 per µg/m3 |
| Asbestos | 1332-21-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer and mesothelioma | 2.3 x 10 -1 per f/mL |
| Benzo[a]pyrene (BaP) | 50-32-8 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Squamous cell neoplasia in the larynx, pharynx, trachea, nasal cavity, esophagus, and forestomach. | 6 x 10 -4 per µg/m3 |
| Benzotrichloride | 98-07-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Lung, adenocarcinoma | 3.6 x 10 -4 per µg/L |
| Beryllium and compounds | 7440-41-7 | Inhalation |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) Carcinogenic potential cannot be determined (1996 guidelines) Known/likely human carcinogen (1996 guidelines) |
Lung cancer | 2.4 x 10 -3 per µg/m3 |
| Bis(chloromethyl)ether (BCME) | 542-88-1 | Oral |
A (Human carcinogen) (1986 guidelines) |
Respiratory tract tumors | 6.2 x 10 -3 per µg/L |
| Bis(chloromethyl)ether (BCME) | 542-88-1 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Respiratory tract tumors | 6.2 x 10 -2 per µg/m3 |
| Cadmium | 7440-43-9 | Inhalation |
B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans) (1986 guidelines) |
Lung, trachea, bronchus cancer deaths | 1.8 x 10 -3 per µg/m3 |
| Chloroprene | 126-99-8 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma | 3 x 10 -4 per µg/m3 |
| Chromium(VI) | 18540-29-9 | Inhalation |
Carcinogenic to humans (2005 guidelines) Likely to be carcinogenic to humans (2005 guidelines) |
Lung cancer | 0.018 per µg/m3 |
| Coke oven emissions | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Respiratory cancer | 6.2 x 10 -4 per µg/m3 | |
| 1,2-Dibromoethane | 106-93-4 | Inhalation |
Likely to be carcinogenic to humans (1999 guidelines) |
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas |
6 x 10 -4 per µg/m3 95% upper bound |
| 1,2-Dibromoethane | 106-93-4 | Inhalation |
Likely to be carcinogenic to humans (1999 guidelines) |
Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas |
3 x 10 -4 per µg/m3 central tendency estimate |
| Dichloromethane | 75-09-2 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas | 1 x 10 -8 per µg/m3 |
| 1,3-Dichloropropene | 542-75-6 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Bronchioalveolar adenoma | 4 x 10 -6 per µg/m3 |
| 1,4-Dioxane | 123-91-1 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) | 5 x 10 -6 per µg/m3 |
| Epichlorohydrin | 106-89-8 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal cavity tumors | 1.2 x 10 -6 per µg/m3 |
| Formaldehyde | 50-00-0 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Nasopharyngeal cancer, sinonasal cancer, myeloid leukemia | 1.1 x 10 -5 per µg/m3 |
| Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) | 121-82-4 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas) | |
| Hydrazine/Hydrazine sulfate | 302-01-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal cavity adenoma or adenocarcinoma | 4.9 x 10 -3 per µg/m3 |
| Libby Amphibole Asbestos | 1318-09-8 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Cancer mortality from lung cancer and mesothelioma | 1.7 x 10 -1 per fiber/cc |
| Nickel refinery dust | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer | 2.4 x 10 -4 per µg/m3 | |
| Nickel subsulfide | 12035-72-2 | Inhalation |
A (Human carcinogen) (1986 guidelines) |
Lung cancer | 4.8 x 10 -4 per µg/m3 |
| Propylene oxide | 75-56-9 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Nasal cavity hemangioma or hemangiosarcoma | 3.7 x 10 -6 per µg/m3 |