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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Developmental"
Number of records: 42
Chemical Name CASRN Exposure Route Critical Effect RfD/RfC RfD/RfC Value
Acifluorfen, sodium 62476-59-9 Oral Mortality and kidney lesions RFD 1.3 x 10 -2 mg/kg-day
Acrylic acid 79-10-7 Oral Reduced pup weight RFD 5 x 10 -1 mg/kg-day
Aroclor 1016 12674-11-2 Oral Reduced birth weights RFD 7 x 10 -5 mg/kg-day
Avermectin B1 65195-55-3 Oral Increased retinal folds in weanlings, decreased viability and lactation indices, decreased pup body weight, increase of dead pups at birth RFD 4 x 10 -4 mg/kg-day
Benomyl 17804-35-2 Oral Decreased pup weanling weights RFD 5 x 10 -2 mg/kg-day
Benzo[a]pyrene (BaP) 50-32-8 Oral Neurobehavioral changes RFD 3 x 10 -4 mg/kg-day
Benzo[a]pyrene (BaP) 50-32-8 Inhalation Decreased embryo/fetal survival RFC 2 x 10 -6 mg/m3
Boron and Compounds 7440-42-8 Oral Decreased fetal weight (developmental) RFD 2 x 10 -1 mg/kg-day
Caprolactam 105-60-2 Oral Reduced offspring body weight RFD 5 x 10 -1 mg/kg-day
Carbon disulfide 75-15-0 Oral Fetal toxicity/ malformations RFD 1 x 10 -1 mg/kg-day
Chlorine dioxide 10049-04-4 Oral Neurodevelopmental effects RFD 3 x 10 -2 mg/kg-day
Chlorite (sodium salt) 7758-19-2 Oral Neurodevelopmental effects RFD 3 x 10 -2 mg/kg-day
Cyclohexane 110-82-7 Inhalation Reduced pup weights in the F1 and F2 generations RFC 6 mg/m3
Cyhalothrin/Karate 68085-85-8 Oral Reduced body weight gain preceding pregnancy reduced body weight gain in offspring during weaning period RFD 5 x 10 -3 mg/kg-day
Di(2-ethylhexyl)adipate 103-23-1 Oral Changes in body weight and liver weight increased liver weight of male and female parents reduced ossification and slightly dilated ureters in fetuses reduced offspring weight gain, total litter weight, and litter size RFD 6 x 10 -1 mg/kg-day
Dicamba 1918-00-9 Oral Maternal (reduced weight gain) and fetal toxicity RFD 3 x 10 -2 mg/kg-day
Dinoseb 88-85-7 Oral Decreased fetal weight RFD 1 x 10 -3 mg/kg-day
Ethyl chloride 75-00-3 Inhalation Delayed fetal ossification RFC 1 x 10 1 mg/m3
Ethylbenzene 100-41-4 Inhalation Developmental toxicity RFC 1 mg/m3
Glyphosate 1071-83-6 Oral Increased incidence of renal tubular dilation in F3b offspring RFD 1 x 10 -1 mg/kg-day
Methanol 67-56-1 Oral Extra cervical ribs RFD 2 mg/kg-day
Methanol 67-56-1 Inhalation Reduced brain weight in rat pups at 6 weeks of age RFC 2 x 10 1 mg/m3
Methoxychlor 72-43-5 Oral Excessive loss of litters RFD 5 x 10 -3 mg/kg-day
Methyl ethyl ketone (MEK) 78-93-3 Inhalation Developmental toxicity (skeletal variations) RFC 5 mg/m3
Methyl ethyl ketone (MEK) 78-93-3 Oral Decreased pup body weight RFD 6 x 10 -1 mg/kg-day
Methyl isobutyl ketone (MIBK) 108-10-1 Inhalation Reduced fetal body weight, skeletal variations, and increased fetal death in mice, and skeletal variations in rats. RFC 3 mg/m3
Methylmercury (MeHg) 22967-92-6 Oral Developmental neuropsychological impairment RFD 1 x 10 -4 mg/kg-day
Methylmercury (MeHg) 22967-92-6 Oral Developmental neuropsychological impairment RFD 1 x 10 -4 mg/kg-day
Nitroguanidine 556-88-7 Oral Reduced weight gain in female rats, maternal/ fetal toxicity in rats, and equivocal evidence of developmental toxicity in rabbits RFD 1 x 10 -1 mg/kg-day
Perfluorobutanoic Acid (PFBA) 375-22-4 Oral Developmental delays RFD 6 x 10 -3 mg/kg-day
Perfluorobutanoic Acid (PFBA) 375-22-4 Oral Developmental delays RFD 6 x 10 -3 mg/kg-day
Perfluorobutanoic Acid (PFBA) 375-22-4 Oral Developmental delays RFD 6 x 10 -3 mg/kg-day
Perfluorohexanoic Acid (PFHxA) 307-24-4 Oral Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats RFD 5 x 10 -4 mg/kg-day
Perfluorohexanoic Acid (PFHxA) 307-24-4 Oral Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats RFD 5 x 10 -4 mg/kg-day
Propargite 2312-35-8 Oral Reduced body weight gain (maternal), increased resorption, reduced body weight (fetal), delayed ossification RFD 2 x 10 -2 mg/kg-day
Rotenone 83-79-4 Oral Reduced pup weight RFD 4 x 10 -3 mg/kg-day
2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 Oral Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates RFD 7 x 10 -10 mg/kg-day
Tetrahydrofuran 109-99-9 Oral Decreased pup body weight gain RFD 9 x 10 -1 mg/kg-day
Trichloroethylene 79-01-6 Inhalation (See Note) RFC 2 x 10 -3 mg/m3
Trichloroethylene 79-01-6 Oral (See Note) RFD 5 x 10 -4 mg/kg-day
1,2,4-Trimethylbenzene 95-63-6 Inhalation Decreased fetal weight RFC 4 mg/m3
1,3,5-Trimethylbenzene 108-67-8 Inhalation Decreased fetal weight RFC 4 mg/m3