IRIS
IRIS Home | Critical Effect Search Results
Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the
RfD, RfC, oral slope factor, or inhalation unit risk.
Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with
organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see
Quick Check: Assessments in Development.
Search Filtered by: Critical Effect = "Developmental"
Number of records: 44
| Chemical Name | CASRN | Exposure Route | Critical Effect | RfD/RfC | RfD/RfC Value |
|---|---|---|---|---|---|
| Acifluorfen, sodium | 62476-59-9 | Oral | Mortality and kidney lesions | RFD | 1.3 x 10 -2 mg/kg-day |
| Acrylic acid | 79-10-7 | Oral | Reduced pup weight | RFD | 5 x 10 -1 mg/kg-day |
| Aroclor 1016 | 12674-11-2 | Oral | Reduced birth weights | RFD | 7 x 10 -5 mg/kg-day |
| Avermectin B1 | 65195-55-3 | Oral | Increased retinal folds in weanlings, decreased viability and lactation indices, decreased pup body weight, increase of dead pups at birth | RFD | 4 x 10 -4 mg/kg-day |
| Benomyl | 17804-35-2 | Oral | Decreased pup weanling weights | RFD | 5 x 10 -2 mg/kg-day |
| Benzo[a]pyrene (BaP) | 50-32-8 | Inhalation | Decreased embryo/fetal survival | RFC | 2 x 10 -6 mg/m3 |
| Benzo[a]pyrene (BaP) | 50-32-8 | Oral | Neurobehavioral changes | RFD | 3 x 10 -4 mg/kg-day |
| Boron and Compounds | 7440-42-8 | Oral | Decreased fetal weight (developmental) | RFD | 2 x 10 -1 mg/kg-day |
| Caprolactam | 105-60-2 | Oral | Reduced offspring body weight | RFD | 5 x 10 -1 mg/kg-day |
| Carbon disulfide | 75-15-0 | Oral | Fetal toxicity/ malformations | RFD | 1 x 10 -1 mg/kg-day |
| Chlorine dioxide | 10049-04-4 | Oral | Neurodevelopmental effects | RFD | 3 x 10 -2 mg/kg-day |
| Chlorite (sodium salt) | 7758-19-2 | Oral | Neurodevelopmental effects | RFD | 3 x 10 -2 mg/kg-day |
| Cyclohexane | 110-82-7 | Inhalation | Reduced pup weights in the F1 and F2 generations | RFC | 6 mg/m3 |
| Cyhalothrin/Karate | 68085-85-8 | Oral | Reduced body weight gain preceding pregnancy reduced body weight gain in offspring during weaning period | RFD | 5 x 10 -3 mg/kg-day |
| Di(2-ethylhexyl)adipate | 103-23-1 | Oral | Changes in body weight and liver weight increased liver weight of male and female parents reduced ossification and slightly dilated ureters in fetuses reduced offspring weight gain, total litter weight, and litter size | RFD | 6 x 10 -1 mg/kg-day |
| Dicamba | 1918-00-9 | Oral | Maternal (reduced weight gain) and fetal toxicity | RFD | 3 x 10 -2 mg/kg-day |
| Dinoseb | 88-85-7 | Oral | Decreased fetal weight | RFD | 1 x 10 -3 mg/kg-day |
| Ethyl chloride | 75-00-3 | Inhalation | Delayed fetal ossification | RFC | 1 x 10 1 mg/m3 |
| Ethylbenzene | 100-41-4 | Inhalation | Developmental toxicity | RFC | 1 mg/m3 |
| Glyphosate | 1071-83-6 | Oral | Increased incidence of renal tubular dilation in F3b offspring | RFD | 1 x 10 -1 mg/kg-day |
| Methanol | 67-56-1 | Oral | Extra cervical ribs | RFD | 2 mg/kg-day |
| Methanol | 67-56-1 | Inhalation | Reduced brain weight in rat pups at 6 weeks of age | RFC | 2 x 10 1 mg/m3 |
| Methoxychlor | 72-43-5 | Oral | Excessive loss of litters | RFD | 5 x 10 -3 mg/kg-day |
| Methyl ethyl ketone (MEK) | 78-93-3 | Inhalation | Developmental toxicity (skeletal variations) | RFC | 5 mg/m3 |
| Methyl ethyl ketone (MEK) | 78-93-3 | Oral | Decreased pup body weight | RFD | 6 x 10 -1 mg/kg-day |
| Methyl isobutyl ketone (MIBK) | 108-10-1 | Inhalation | Reduced fetal body weight, skeletal variations, and increased fetal death in mice, and skeletal variations in rats. | RFC | 3 mg/m3 |
| Methylmercury (MeHg) | 22967-92-6 | Oral | Developmental neuropsychological impairment | RFD | 1 x 10 -4 mg/kg-day |
| Methylmercury (MeHg) | 22967-92-6 | Oral | Developmental neuropsychological impairment | RFD | 1 x 10 -4 mg/kg-day |
| Nitroguanidine | 556-88-7 | Oral | Reduced weight gain in female rats, maternal/ fetal toxicity in rats, and equivocal evidence of developmental toxicity in rabbits | RFD | 1 x 10 -1 mg/kg-day |
| Perfluorobutanoic Acid (PFBA) | 375-22-4 | Oral | Developmental delays | RFD | 6 x 10 -3 mg/kg-day |
| Perfluorobutanoic Acid (PFBA) | 375-22-4 | Oral | Developmental delays | RFD | 6 x 10 -3 mg/kg-day |
| Perfluorobutanoic Acid (PFBA) | 375-22-4 | Oral | Developmental delays | RFD | 6 x 10 -3 mg/kg-day |
| Perfluorodecanoic Acid (PFDA) | 335-76-2 | Oral | Decreased serum antibody concentrations for tetanus and diphtheria in children; Decreased birth weight in male and female children | RFD | 2 x 10 -9 mg/kg-day |
| Perfluorodecanoic Acid (PFDA) | 335-76-2 | Oral | Decreased serum antibody concentrations for tetanus and diphtheria in children; Decreased birth weight in male and female children | RFD | 2 x 10 -9 mg/kg-day |
| Perfluorohexanoic Acid (PFHxA) | 307-24-4 | Oral | Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats | RFD | 5 x 10 -4 mg/kg-day |
| Perfluorohexanoic Acid (PFHxA) | 307-24-4 | Oral | Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats | RFD | 5 x 10 -4 mg/kg-day |
| Propargite | 2312-35-8 | Oral | Reduced body weight gain (maternal), increased resorption, reduced body weight (fetal), delayed ossification | RFD | 2 x 10 -2 mg/kg-day |
| Rotenone | 83-79-4 | Oral | Reduced pup weight | RFD | 4 x 10 -3 mg/kg-day |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin | 1746-01-6 | Oral | Decreased sperm count and motility in men exposed to TCDD as boys / Increased TSH in neonates | RFD | 7 x 10 -10 mg/kg-day |
| Tetrahydrofuran | 109-99-9 | Oral | Decreased pup body weight gain | RFD | 9 x 10 -1 mg/kg-day |
| Trichloroethylene | 79-01-6 | Inhalation | (See Note) | RFC | 2 x 10 -3 mg/m3 |
| Trichloroethylene | 79-01-6 | Oral | (See Note) | RFD | 5 x 10 -4 mg/kg-day |
| 1,3,5-Trimethylbenzene | 108-67-8 | Inhalation | Decreased fetal weight | RFC | 4 mg/m3 |
| 1,2,4-Trimethylbenzene | 95-63-6 | Inhalation | Decreased fetal weight | RFC | 4 mg/m3 |