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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Respiratory"
Number of records: 47
Chemical Name CASRN Exposure Route Critical Effect RfD/RfC RfD/RfC Value
Acetaldehyde 75-07-0 Inhalation Degeneration of olfactory epithelium RFC 9 x 10 -3 mg/m3
Acrolein 107-02-8 Inhalation Nasal lesions RFC 2 x 10 -5 mg/m3
Acrylic acid 79-10-7 Inhalation Degeneration of the nasal olfactory epithelium RFC 1 x 10 -3 mg/m3
Acrylonitrile 107-13-1 Inhalation Degeneration and inflammation of nasal respiratory epithelium; hyperplasia of mucous secreting cells RFC 2 x 10 -3 mg/m3
Ammonia 7664-41-7 Inhalation Decreased lung function and respiratory symptoms RFC 5 x 10 -1 mg/m3
Antimony trioxide 1309-64-4 Inhalation Pulmonary toxicity, chronic interstitial inflammation RFC 2 x 10 -4 mg/m3
Beryllium and compounds 7440-41-7 Inhalation Beryllium sensitization and progression to CBD RFC 2 x 10 -5 mg/m3
Bromomethane 74-83-9 Inhalation Degenerative and proliferative lesions of the olfactory epithelium of the nasal cavity RFC 5 x 10 -3 mg/m3
Cerium Oxide and Cerium Compounds 1306-38-3 Inhalation Increased incidence of alveolar epithelial hyperplasia in the lungs of male and female rats RFC 9 x 10 -4 mg/m3
Chlorine dioxide 10049-04-4 Inhalation Vascular congestion and peribronchial edema RFC 2 x 10 -4 mg/m3
2-Chloroacetophenone 532-27-4 Inhalation Squamous hyperplasia of the nasal respiratory epithelium RFC 3 x 10 -5 mg/m3
beta-Chloronaphthalene 91-58-7 Oral Dyspnea, abnormal appearance, liver enlargement RFD 8 x 10 -2 mg/kg-day
Chloroprene 126-99-8 Inhalation Increase in incidence of olfactory atrophy, alveolar hyperplasia, and splenic hematopoietic proliferation in male F344/N rats, female F344/N rats, and female B6C3F1 mice, respectively RFC 2 x 10 -2 mg/m3
Chromium(VI) 18540-29-9 Inhalation Ulcerated nasal septum in humans RFC 3 x 10 -5 mg/m3
Dacthal 1861-32-1 Oral Effects on the lungs, liver, kidney, thyroid and thyroid hormones in males and females and eyes of females RFD 1 x 10 -2 mg/kg-day
1,2-Dibromoethane 106-93-4 Inhalation Nasal inflammation RFC 9 x 10 -3 mg/m3
1,2-Dichloropropane 78-87-5 Inhalation Hyperplasia of the nasal mucosa RFC 4 x 10 -3 mg/m3
1,3-Dichloropropene 542-75-6 Inhalation Hypertrophy/ hyperplasia of the nasal respiratory epithelium RFC 2 x 10 -2 mg/m3
Diesel engine exhaust Inhalation Pulmonary inflammation and histopathology RFC 5 x 10 -3 mg/m3
1,4-Dioxane 123-91-1 Inhalation Atrophy and respiratory metaplasia of the olfactory epithelium RFC 3 x 10 -2 mg/m3
1,4-Dithiane 505-29-3 Oral Nasal olfactory lesions RFD 1 x 10 -2 mg/kg-day
Epichlorohydrin 106-89-8 Inhalation Changes in the nasal turbinates RFC 1 x 10 -3 mg/m3
1,2-Epoxybutane (EBU) 106-88-7 Inhalation Degenerative lesions of the nasal cavity RFC 2 x 10 -2 mg/m3
Formaldehyde 50-00-0 Inhalation Decreased pulmonary function, prevalence of current asthma or degree of asthma control, and allergic conditions in children (See Note) RFC 7 x 10 -3 mg/m3
Hexachlorocyclopentadiene (HCCPD) 77-47-4 Inhalation Suppurative inflammation of the nose RFC 2 x 10 -4 mg/m3
1,6-Hexamethylene diisocyanate 822-06-0 Inhalation Degeneration of olfactory epithelium RFC 1 x 10 -5 mg/m3
Hydrogen chloride 7647-01-0 Inhalation Hyperplasia of nasal mucosa larynx and trachea RFC 2 x 10 -2 mg/m3
Hydrogen sulfide 7783-06-4 Inhalation Nasal lesions of the olfactory mucosa RFC 2 x 10 -3 mg/m3
Libby Amphibole Asbestos 1318-09-8 Inhalation Localized pleural thickening RFC 9 x 10 -5 fiber/cc
Methyl methacrylate 80-62-6 Inhalation Degeneration/ atrophy of olfactory epithelium (male rats) RFC 7 x 10 -1 mg/m3
Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) 101-68-8 Inhalation Hyperplasia of olfactory epithelium RFC 6 x 10 -4 mg/m3
2-Methylnaphthalene 91-57-6 Oral Pulmonary alveolar proteinosis RFD 4 x 10 -3 mg/kg-day
Naphthalene 91-20-3 Inhalation Nasal effects: hyperplasia and metaplasia in respiratory and olfactory epithelium, respectively RFC 3 x 10 -3 mg/m3
Nitrobenzene 98-95-3 Inhalation Bronchiolization of the alveoli and olfactory degeneration RFC 9 x 10 -3 mg/m3
Paraquat 1910-42-5 Oral Chronic pneumonitis RFD 4.5 x 10 -3 mg/kg-day
Phosgene 75-44-5 Inhalation Collagen staining indicative of fibrosis RFC 3 x 10 -4 mg/m3
Phosphoric acid 7664-38-2 Inhalation Bronchiolar fibrosis RFC 1 x 10 -2 mg/m3
Phthalic anhydride 85-44-9 Oral Lung and kidney histopathology RFD 2 mg/kg-day
Propionaldehyde 123-38-6 Inhalation Atrophy of olfactory epithelium RFC 8 x 10 -3 mg/m3
Propylene oxide 75-56-9 Inhalation Nest-like infolds of the nasal respiratory epithelium RFC 3 x 10 -2 mg/m3
2,4-/2,6-Toluene diisocyanate mixture (TDI) 26471-62-5 Inhalation Chronic lung-function decline RFC 7 x 10 -5 mg/m3
Trichlorofluoromethane 75-69-4 Oral Survival and histopathology (pleuritis and pericarditis) RFD 3 x 10 -1 mg/kg-day
1,2,3-Trichloropropane 96-18-4 Inhalation peribronchial lymphoid hyperplasia in male rats RFC 3 x 10 -4 mg/m3
Triethylamine 121-44-8 Inhalation Inflammation of the nasal passage RFC 7 x 10 -3 mg/m3
1,2,4-Trimethylbenzene 95-63-6 Inhalation Inflammatory lung lesions RFC 2 x 10 -1 mg/m3
1,2,3-Trimethylbenzene 526-73-8 Inhalation Inflammatory lung lesions RFC 2 x 10 -1 mg/m3
Vinyl acetate 108-05-4 Inhalation Nasal epithelial lesions RFC 2 x 10 -1 mg/m3