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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the
RfD, RfC, oral slope factor, or inhalation unit risk.
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Search Filtered by: Tumor Site = "Hepatic"
Number of records: 88
| Chemical Name | CASRN | Exposure Route | WOE Characterization | Tumor Type | Toxicity Value |
|---|---|---|---|---|---|
| Aldrin | 309-00-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma | 4.9 x 10 -3 per µg/m3 |
| Aldrin | 309-00-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma | 4.9 x 10 -4 per µg/L |
| Aramite | 140-57-8 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic liver nodules and carcinomas | 7.1 x 10 -6 per µg/m3 |
| Aramite | 140-57-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Neoplastic liver nodules and carcinomas | 7.1 x 10 -7 per µg/L |
| Biphenyl | 92-52-4 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Liver adenomas or carcinomas | 2.3 x 10 -7 per µg/L |
| Bis(chloroethyl)ether (BCEE) | 111-44-4 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatomas | 3.3 x 10 -4 per µg/m3 |
| Bis(chloroethyl)ether (BCEE) | 111-44-4 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatomas | 3.3 x 10 -5 per µg/L |
| Carbon tetrachloride | 56-23-5 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenoma or carcinoma | 2 x 10 -6 per µg/L |
| Chlordane (Technical) | 12789-03-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular carcinoma | 1 x 10 -5 per µg/L |
| Chlordane (Technical) | 12789-03-6 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular carcinoma | 1 x 10 -4 per µg/m3 |
| Chlordecone (Kepone) | 143-50-0 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
liver hepatocellular carcinoma | 3 x 10 -4 per µg/L |
| Chloroform | 67-66-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Likely to be carcinogenic to humans (1999 guidelines) Not likely to be carcinogenic to humans (1999 guidelines) |
Hepatocellular carcinoma | 2.3 x 10 -5 per µg/m3 |
| Chloroprene | 126-99-8 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma | 3 x 10 -4 per µg/m3 |
| 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) | 1163-19-5 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Liver neoplastic nodules or carcinoma (combined) | 2 x 10 -8 per µg/L |
| Di (2-ethylhexyl)phthalate (DEHP) | 117-81-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma and adenoma | 4 x 10 -7 per µg/L |
| Di (2-ethylhexyl)phthalate (DEHP) | 117-81-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma and adenoma | 4 x 10 -7 per µg/L |
| Di(2-ethylhexyl)adipate | 103-23-1 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Combined hepatocellular adenomas and carcinomas | 3.4 x 10 -8 per µg/L |
| Dibromochloromethane | 124-48-1 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular adenoma or carcinoma | 2.4 x 10 -6 per µg/L |
| Dichloroacetic acid | 79-43-6 | Oral |
Likely to be carcinogenic to humans (1999 guidelines) |
Hepatoadenoma and Hepatocarcinoma | 1.4 x 10 -6 per µg/L |
| p,p'-Dichlorodiphenyl dichloroethane (DDD) | 72-54-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors | 6.9 x 10 -6 per µg/L |
| p,p'-Dichlorodiphenyldichloroethylene (DDE) | 72-55-9 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas, hepatomas | 9.7 x 10 -6 per µg/L |
| p,p'-Dichlorodiphenyltrichloroethane (DDT) | 50-29-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors, benign and malignant | 9.7 x 10 -5 per µg/m3 |
| p,p'-Dichlorodiphenyltrichloroethane (DDT) | 50-29-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors, benign and malignant | 9.7 x 10 -6 per µg/L |
| Dichloromethane | 75-09-2 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular carcinomas or adenomas | |
| Dichloromethane | 75-09-2 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas | 1 x 10 -8 per µg/m3 |
| 1,3-Dichloropropene | 542-75-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular adenoma/carcinoma | 2 x 10 -6 per µg/L |
| 1,3-Dichloropropene | 542-75-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatocellular adenoma/carcinoma | 1 x 10 -6 per µg/L |
| Dieldrin | 60-57-1 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma | 4.6 x 10 -3 per µg/m3 |
| Dieldrin | 60-57-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver carcinoma | 4.6 x 10 -4 per µg/L |
| 2,4-/2,6-Dinitrotoluene mixture | Various | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas | 1.9 x 10 -5 per µg/L |
| 1,4-Dioxane | 123-91-1 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) | 5 x 10 -6 per µg/m3 |
| 1,4-Dioxane | 123-91-1 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenoma and carcinoma | 2.9 x 10 -6 per µg/L |
| 1,2-Diphenylhydrazine | 122-66-7 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic liver nodules | 2.2 x 10 -4 per µg/m3 |
| 1,2-Diphenylhydrazine | 122-66-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic liver nodules | 2.2 x 10 -5 per µg/L |
| Ethyl Tertiary Butyl Ether (ETBE) | 637-92-3 | Inhalation |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Hepatocellular adenomas and carcinomas | 8 x 10 -5 per mg/m3 |
| Furmecyclox | 60568-05-0 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Combined liver nodules and carcinomas | 8.6 x 10 -7 per µg/L |
| Heptachlor | 76-44-8 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas | 1.3 x 10 -3 per µg/m3 |
| Heptachlor | 76-44-8 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas | 1.3 x 10 -4 per µg/L |
| Heptachlor epoxide | 1024-57-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas | 2.6 x 10 -3 per µg/m3 |
| Heptachlor epoxide | 1024-57-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas | 2.6 x 10 -4 per µg/L |
| Hexachlorobenzene | 118-74-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma | 4.6 x 10 -5 per µg/L |
| Hexachlorobenzene | 118-74-1 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma | 4.6 x 10 -4 per µg/m3 |
| alpha-Hexachlorocyclohexane (alpha-HCH) | 319-84-6 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas | 1.8 x 10 -3 per µg/m3 |
| alpha-Hexachlorocyclohexane (alpha-HCH) | 319-84-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas | 1.8 x 10 -4 per µg/L |
| beta-Hexachlorocyclohexane (beta-HCH) | 319-85-7 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas | 5.3 x 10 -5 per µg/L |
| beta-Hexachlorocyclohexane (beta-HCH) | 319-85-7 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Hepatic nodules and hepatocellular carcinomas | 5.3 x 10 -4 per µg/m3 |
| technical Hexachlorocyclohexane (t-HCH) | 608-73-1 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver nodules and hepatocellular carcinomas | 5.1 x 10 -5 per µg/L |
| technical Hexachlorocyclohexane (t-HCH) | 608-73-1 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver nodules and hepatocellular carcinomas | 5.1 x 10 -4 per µg/m3 |
| Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD | 57653-85-7 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) | 1.3 per µg/m3 |
| Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD | 57653-85-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) | 1.8 x 10 -1 per µg/L |
| Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) | 121-82-4 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas) | |
| Hydrazine/Hydrazine sulfate | 302-01-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatoma | 8.5 x 10 -5 per µg/L |
| Nitrobenzene | 98-95-3 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomas | 4 x 10 -5 per µg/m3 |
| N-Nitroso-N-methylethylamine | 10595-95-6 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas | 6.3 x 10 -4 per µg/L |
| N-Nitrosodi-N-propylamine | 621-64-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas | 2.0 x 10 -4 per µg/L |
| N-Nitrosodiethanolamine | 1116-54-7 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma, cholangiocellular carcinoma and adenoma and neoplastic nodules | 8.0 x 10 -5 per µg/L |
| N-Nitrosodiethylamine | 55-18-5 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors | 4.3 x 10 -2 per µg/m3 |
| N-Nitrosodiethylamine | 55-18-5 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors | 4.3 x 10 -3 per µg/L |
| N-Nitrosodimethylamine | 62-75-9 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors | 1.4 x 10 -3 per µg/L |
| N-Nitrosodimethylamine | 62-75-9 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver tumors | 1.4 x 10 -2 per µg/m3 |
| N-Nitrosopyrrolidine | 930-55-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma and adenoma | 6.1 x 10 -4 per µg/m3 |
| N-Nitrosopyrrolidine | 930-55-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinoma and adenoma | 6.1 x 10 -5 per µg/L |
| Pentachlorophenol | 87-86-5 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenomas or carcinomas and adrenal benign or malignant pheochromocytomas | 1.1 x 10 -5 per µg/L |
| Polychlorinated Biphenyls (PCBs) | 1336-36-3 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas | |
| Polychlorinated Biphenyls (PCBs) | 1336-36-3 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas |
1 x 10 -4 per µg/m3 Applies to inhalation of evaporated congeners |
| Prochloraz | 67747-09-5 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Liver adenoma/ carcinoma combined | 4.3 x 10 -6 per µg/L |
| Quinoline | 91-22-5 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Hepatic hemangioendotheliomas or hemangiosarcomas | 9 x 10 -5 per µg/L |
| 1,1,1,2-Tetrachloroethane | 630-20-6 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular adenoma or carcinoma | 7.4 x 10 -7 per µg/L |
| 1,1,1,2-Tetrachloroethane | 630-20-6 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular adenoma or carcinoma | 7.4 x 10 -6 per µg/m3 |
| 1,1,2,2-Tetrachloroethane | 79-34-5 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
hepatocellular carcinomas | 6 x 10 -6 per µg/L |
| Tetrachloroethylene (Perchloroethylene) | 127-18-4 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenomas or carcinomas | 6.1 x 10 -8 per µg/L |
| Tetrachloroethylene (Perchloroethylene) | 127-18-4 | Inhalation |
Likely to be carcinogenic to humans (2005 guidelines) |
Hepatocellular adenomas or carcinomas | 2.6 x 10 -7 per µg/m3 |
| Toxaphene | 8001-35-2 | Inhalation |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic nodules | 3.2 x 10 -4 per µg/m3 |
| Toxaphene | 8001-35-2 | Oral |
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines) |
Hepatocellular carcinomas and neoplastic nodules | 3.2 x 10 -5 per µg/L |
| Trichloroacetic acid | 76-03-9 | Oral |
Suggestive evidence of carcinogenic potential (2005 guidelines) |
Hepatocellular adenomas or carcinomas | 2 x 10 -6 per µg/L |
| 1,1,2-Trichloroethane | 79-00-5 | Inhalation |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular carcinoma | 1.6 x 10 -5 per µg/m3 |
| 1,1,2-Trichloroethane | 79-00-5 | Oral |
C (Possible human carcinogen) (1986 guidelines) |
Hepatocellular carcinoma | 1.6 x 10 -6 per µg/L |
| Trichloroethylene | 79-01-6 | Oral |
Carcinogenic to humans (2005 guidelines) |
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors | |
| Trichloroethylene | 79-01-6 | Inhalation |
Carcinogenic to humans (2005 guidelines) |
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors | 4.1 x 10 -6 per µg/m3 |
| 1,2,3-Trichloropropane | 96-18-4 | Oral |
Likely to be carcinogenic to humans (2005 guidelines) |
alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas | |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
2.1 x 10 -5 per µg/L Continuous lifetime exposure during adulthood |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
2.1 x 10 -5 per µg/L Continuous lifetime exposure during adulthood |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
4.2 x 10 -5 per µg/L Continuous lifetime exposure from birth |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
8.8 x 10 -6 per µg/m3 Continuous lifetime exposure from birth |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
4.4 x 10 -6 per µg/m3 Continuous lifetime exposure during adulthood |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
8.8 x 10 -6 per µg/m3 Continuous lifetime exposure from birth |
| Vinyl chloride | 75-01-4 | Inhalation |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules |
4.4 x 10 -6 per µg/m3 Continuous lifetime exposure during adulthood |
| Vinyl chloride | 75-01-4 | Oral |
A (Human carcinogen) (1986 guidelines) Known/likely human carcinogen (1996 guidelines) |
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules |
4.2 x 10 -5 per µg/L Continuous lifetime exposure from birth |