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Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Tumor Site = "Hepatic"
Number of records: 88
Chemical Name CASRN Exposure Route WOE Characterization Tumor Type Toxicity Value
Aldrin 309-00-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 4.9 x 10 -3 per µg/m3
Aldrin 309-00-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 4.9 x 10 -4 per µg/L
Aramite 140-57-8 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Neoplastic liver nodules and carcinomas 7.1 x 10 -6 per µg/m3
Aramite 140-57-8 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Neoplastic liver nodules and carcinomas 7.1 x 10 -7 per µg/L
Biphenyl 92-52-4 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Liver adenomas or carcinomas 2.3 x 10 -7 per µg/L
Bis(chloroethyl)ether (BCEE) 111-44-4 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatomas 3.3 x 10 -4 per µg/m3
Bis(chloroethyl)ether (BCEE) 111-44-4 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatomas 3.3 x 10 -5 per µg/L
Carbon tetrachloride 56-23-5 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenoma or carcinoma 2 x 10 -6 per µg/L
Chlordane (Technical) 12789-03-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular carcinoma 1 x 10 -5 per µg/L
Chlordane (Technical) 12789-03-6 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular carcinoma 1 x 10 -4 per µg/m3
Chlordecone (Kepone) 143-50-0 Oral Likely to be carcinogenic to humans (2005 guidelines)
liver hepatocellular carcinoma 3 x 10 -4 per µg/L
Chloroform 67-66-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Likely to be carcinogenic to humans (1999 guidelines)
Not likely to be carcinogenic to humans (1999 guidelines)
Hepatocellular carcinoma 2.3 x 10 -5 per µg/m3
Chloroprene 126-99-8 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
alveolar/ bronchiolar adenoma or carcinoma hemangioma/ hemangiosarcoma (all organs) mammary gland adenocarcinoma, carcinoma, or adenoacanthoma forestomach squamous cell papilloma or carcinoma hepatocellular adenoma or carcinoma Harderian gland adenoma or carcinoma skin sarcoma and Zymbal's gland carcinoma 3 x 10 -4 per µg/m3
2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) 1163-19-5 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Liver neoplastic nodules or carcinoma (combined) 2 x 10 -8 per µg/L
Di (2-ethylhexyl)phthalate (DEHP) 117-81-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma and adenoma 4 x 10 -7 per µg/L
Di (2-ethylhexyl)phthalate (DEHP) 117-81-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma and adenoma 4 x 10 -7 per µg/L
Di(2-ethylhexyl)adipate 103-23-1 Oral C (Possible human carcinogen) (1986 guidelines)
Combined hepatocellular adenomas and carcinomas 3.4 x 10 -8 per µg/L
Dibromochloromethane 124-48-1 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatocellular adenoma or carcinoma 2.4 x 10 -6 per µg/L
Dichloroacetic acid 79-43-6 Oral Likely to be carcinogenic to humans (1999 guidelines)
Hepatoadenoma and Hepatocarcinoma 1.4 x 10 -6 per µg/L
p,p'-Dichlorodiphenyl dichloroethane (DDD) 72-54-8 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 6.9 x 10 -6 per µg/L
p,p'-Dichlorodiphenyldichloroethylene (DDE) 72-55-9 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas, hepatomas 9.7 x 10 -6 per µg/L
p,p'-Dichlorodiphenyltrichloroethane (DDT) 50-29-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors, benign and malignant 9.7 x 10 -6 per µg/L
p,p'-Dichlorodiphenyltrichloroethane (DDT) 50-29-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors, benign and malignant 9.7 x 10 -5 per µg/m3
Dichloromethane 75-09-2 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomas 1 x 10 -8 per µg/m3
Dichloromethane 75-09-2 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular carcinomas or adenomas
1,3-Dichloropropene 542-75-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular adenoma/carcinoma 2 x 10 -6 per µg/L
1,3-Dichloropropene 542-75-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatocellular adenoma/carcinoma 1 x 10 -6 per µg/L
Dieldrin 60-57-1 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 4.6 x 10 -3 per µg/m3
Dieldrin 60-57-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver carcinoma 4.6 x 10 -4 per µg/L
2,4-/2,6-Dinitrotoluene mixture Various Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas 1.9 x 10 -5 per µg/L
1,4-Dioxane 123-91-1 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenoma and carcinoma 2.9 x 10 -6 per µg/L
1,4-Dioxane 123-91-1 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Multiple (nasal, liver, kidney, peritoneal, mammary gland, and Zymbal gland) 5 x 10 -6 per µg/m3
1,2-Diphenylhydrazine 122-66-7 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic liver nodules 2.2 x 10 -4 per µg/m3
1,2-Diphenylhydrazine 122-66-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic liver nodules 2.2 x 10 -5 per µg/L
Ethyl Tertiary Butyl Ether (ETBE) 637-92-3 Inhalation Suggestive evidence of carcinogenic potential (2005 guidelines)
Hepatocellular adenomas and carcinomas 8 x 10 -5 per mg/m3
Furmecyclox 60568-05-0 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Combined liver nodules and carcinomas 8.6 x 10 -7 per µg/L
Heptachlor 76-44-8 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 1.3 x 10 -4 per µg/L
Heptachlor 76-44-8 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 1.3 x 10 -3 per µg/m3
Heptachlor epoxide 1024-57-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 2.6 x 10 -4 per µg/L
Heptachlor epoxide 1024-57-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 2.6 x 10 -3 per µg/m3
Hexachlorobenzene 118-74-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma 4.6 x 10 -5 per µg/L
Hexachlorobenzene 118-74-1 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma 4.6 x 10 -4 per µg/m3
alpha-Hexachlorocyclohexane (alpha-HCH) 319-84-6 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 1.8 x 10 -3 per µg/m3
alpha-Hexachlorocyclohexane (alpha-HCH) 319-84-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 1.8 x 10 -4 per µg/L
beta-Hexachlorocyclohexane (beta-HCH) 319-85-7 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 5.3 x 10 -5 per µg/L
beta-Hexachlorocyclohexane (beta-HCH) 319-85-7 Inhalation C (Possible human carcinogen) (1986 guidelines)
Hepatic nodules and hepatocellular carcinomas 5.3 x 10 -4 per µg/m3
technical Hexachlorocyclohexane (t-HCH) 608-73-1 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver nodules and hepatocellular carcinomas 5.1 x 10 -4 per µg/m3
technical Hexachlorocyclohexane (t-HCH) 608-73-1 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver nodules and hepatocellular carcinomas 5.1 x 10 -5 per µg/L
Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD 57653-85-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) 1.8 x 10 -1 per µg/L
Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD 57653-85-7 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas) 1.3 per µg/m3
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) 121-82-4 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas)
Hydrazine/Hydrazine sulfate 302-01-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatoma 8.5 x 10 -5 per µg/L
Nitrobenzene 98-95-3 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomas 4 x 10 -5 per µg/m3
N-Nitroso-N-methylethylamine 10595-95-6 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 6.3 x 10 -4 per µg/L
N-Nitrosodi-N-propylamine 621-64-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas 2.0 x 10 -4 per µg/L
N-Nitrosodiethanolamine 1116-54-7 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma, cholangiocellular carcinoma and adenoma and neoplastic nodules 8.0 x 10 -5 per µg/L
N-Nitrosodiethylamine 55-18-5 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 4.3 x 10 -2 per µg/m3
N-Nitrosodiethylamine 55-18-5 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 4.3 x 10 -3 per µg/L
N-Nitrosodimethylamine 62-75-9 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 1.4 x 10 -2 per µg/m3
N-Nitrosodimethylamine 62-75-9 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver tumors 1.4 x 10 -3 per µg/L
N-Nitrosopyrrolidine 930-55-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma and adenoma 6.1 x 10 -5 per µg/L
N-Nitrosopyrrolidine 930-55-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinoma and adenoma 6.1 x 10 -4 per µg/m3
Pentachlorophenol 87-86-5 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenomas or carcinomas and adrenal benign or malignant pheochromocytomas 1.1 x 10 -5 per µg/L
Polychlorinated Biphenyls (PCBs) 1336-36-3 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas 1 x 10 -4 per µg/m3
Applies to inhalation of evaporated congeners
Polychlorinated Biphenyls (PCBs) 1336-36-3 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomas
Prochloraz 67747-09-5 Oral C (Possible human carcinogen) (1986 guidelines)
Liver adenoma/ carcinoma combined 4.3 x 10 -6 per µg/L
Quinoline 91-22-5 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Hepatic hemangioendotheliomas or hemangiosarcomas 9 x 10 -5 per µg/L
1,1,1,2-Tetrachloroethane 630-20-6 Inhalation C (Possible human carcinogen) (1986 guidelines)
Hepatocellular adenoma or carcinoma 7.4 x 10 -6 per µg/m3
1,1,2,2-Tetrachloroethane 79-34-5 Oral Likely to be carcinogenic to humans (2005 guidelines)
hepatocellular carcinomas 6 x 10 -6 per µg/L
1,1,1,2-Tetrachloroethane 630-20-6 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatocellular adenoma or carcinoma 7.4 x 10 -7 per µg/L
Tetrachloroethylene (Perchloroethylene) 127-18-4 Inhalation Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenomas or carcinomas 2.6 x 10 -7 per µg/m3
Tetrachloroethylene (Perchloroethylene) 127-18-4 Oral Likely to be carcinogenic to humans (2005 guidelines)
Hepatocellular adenomas or carcinomas 6.1 x 10 -8 per µg/L
Toxaphene 8001-35-2 Inhalation B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic nodules 3.2 x 10 -4 per µg/m3
Toxaphene 8001-35-2 Oral B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) (1986 guidelines)
Hepatocellular carcinomas and neoplastic nodules 3.2 x 10 -5 per µg/L
Trichloroacetic acid 76-03-9 Oral Suggestive evidence of carcinogenic potential (2005 guidelines)
Hepatocellular adenomas or carcinomas 2 x 10 -6 per µg/L
1,1,2-Trichloroethane 79-00-5 Inhalation C (Possible human carcinogen) (1986 guidelines)
Hepatocellular carcinoma 1.6 x 10 -5 per µg/m3
1,1,2-Trichloroethane 79-00-5 Oral C (Possible human carcinogen) (1986 guidelines)
Hepatocellular carcinoma 1.6 x 10 -6 per µg/L
Trichloroethylene 79-01-6 Inhalation Carcinogenic to humans (2005 guidelines)
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors 4.1 x 10 -6 per µg/m3
Trichloroethylene 79-01-6 Oral Carcinogenic to humans (2005 guidelines)
Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumors
1,2,3-Trichloropropane 96-18-4 Oral Likely to be carcinogenic to humans (2005 guidelines)
alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 2.1 x 10 -5 per µg/L
Continuous lifetime exposure during adulthood
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 2.1 x 10 -5 per µg/L
Continuous lifetime exposure during adulthood
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 8.8 x 10 -6 per µg/m3
Continuous lifetime exposure from birth
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 8.8 x 10 -6 per µg/m3
Continuous lifetime exposure from birth
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 4.4 x 10 -6 per µg/m3
Continuous lifetime exposure during adulthood
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 4.2 x 10 -5 per µg/L
Continuous lifetime exposure from birth
Vinyl chloride 75-01-4 Oral A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Total of liver angiosarcoma, hepatocellular carcinoma, and neoplastic nodules 4.2 x 10 -5 per µg/L
Continuous lifetime exposure from birth
Vinyl chloride 75-01-4 Inhalation A (Human carcinogen) (1986 guidelines)
Known/likely human carcinogen (1996 guidelines)
Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodules 4.4 x 10 -6 per µg/m3
Continuous lifetime exposure during adulthood