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Search Filtered by: Critical Effect = "Nervous"
Number of records: 111
| Chemical Name | CASRN | Exposure Route | Critical Effect | RfD/RfC | RfD/RfC Value |
|---|---|---|---|---|---|
| Acephate | 30560-19-1 | Oral | Inhibition of brain ChE | RFD | 4 x 10 -3 mg/kg-day |
| Acetaldehyde | 75-07-0 | Inhalation | Degeneration of olfactory epithelium | RFC | 9 x 10 -3 mg/m3 |
| Acetochlor | 34256-82-1 | Oral | Salivation, increased ALT and ornithine carbamyl transferase; significant increases in triglyceride and decreased blood glucose levels; histopathological changes in kidneys and testes of males | RFD | 2 x 10 -2 mg/kg-day |
| Acrylamide | 79-06-1 | Inhalation | Degenerative nerve changes | RFC | 6 x 10 -3 mg/m3 |
| Acrylamide | 79-06-1 | Oral | Degenerative nerve changes | RFD | 2 x 10 -3 mg/kg-day |
| Acrylic acid | 79-10-7 | Inhalation | Degeneration of the nasal olfactory epithelium | RFC | 1 x 10 -3 mg/m3 |
| Aldicarb | 116-06-3 | Oral | Sweating as clinical sign of AChe inhibition | RFD | 1 x 10 -3 mg/kg-day |
| Aldicarb sulfone | 1646-88-4 | Oral | Brain ChE inhibition in females | RFD | 1 x 10 -3 mg/kg-day |
| Allyl chloride | 107-05-1 | Inhalation | Functional and histological peripheral neurotoxicity | RFC | 1 x 10 -3 mg/m3 |
| Baygon | 114-26-1 | Oral | Mild cholinergic symptoms and RBD ChE inhibition | RFD | 4 x 10 -3 mg/kg-day |
| Benzidine | 92-87-5 | Oral | Brain cell vacuolization; liver cell alterations in females | RFD | 3 x 10 -3 mg/kg-day |
| Biphenthrin | 82657-04-3 | Oral | Tremors | RFD | 1.5 x 10 -2 mg/kg-day |
| Bromomethane | 74-83-9 | Inhalation | Degenerative and proliferative lesions of the olfactory epithelium of the nasal cavity | RFC | 5 x 10 -3 mg/m3 |
| Carbofuran | 1563-66-2 | Oral | RBC and plasma cholinesterase inhibition, and testicular and uterine effects | RFD | 5 x 10 -3 mg/kg-day |
| Carbon disulfide | 75-15-0 | Inhalation | Peripheral nervous system dysfunction | RFC | 7 x 10 -1 mg/m3 |
| Chloral hydrate | 302-17-0 | Oral | CNS depression and GI irritation in humans | RFD | 1 x 10 -1 mg/kg-day |
| Chlorine cyanide | 506-77-4 | Oral | Weight loss, thyroid effects, and myelin degeneration | RFD | 5 x 10 -2 mg/kg-day |
| Chlorine dioxide | 10049-04-4 | Oral | Neurodevelopmental effects | RFD | 3 x 10 -2 mg/kg-day |
| Chlorite (sodium salt) | 7758-19-2 | Oral | Neurodevelopmental effects | RFD | 3 x 10 -2 mg/kg-day |
| Chlorobenzilate | 510-15-6 | Oral | Decreased stool quantity, food consumption and body weight gains hyperirritability (maternal effects) | RFD | 2 x 10 -2 mg/kg-day |
| Chloroprene | 126-99-8 | Inhalation | Increase in incidence of olfactory atrophy, alveolar hyperplasia, and splenic hematopoietic proliferation in male F344/N rats, female F344/N rats, and female B6C3F1 mice, respectively | RFC | 2 x 10 -2 mg/m3 |
| Cyanogen bromide | 506-68-3 | Oral | Weight loss, thyroid effects and myelin degeneration | RFD | 9 x 10 -2 mg/kg-day |
| Danitol | 39515-41-8 | Oral | Tremors | RFD | 2.5 x 10 -2 mg/kg-day |
| 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) | 1163-19-5 | Oral | Neurobehavioral effects | RFD | 7 x 10 -3 mg/kg-day |
| Demeton | 8065-48-3 | Oral | ChE inhibition, optic nerve degeneration | RFD | 4 x 10 -5 mg/kg-day |
| Dichloroacetic acid | 79-43-6 | Oral | Lesions observed in the testes, cerebrum, cerebellum, and liver. | RFD | 4 x 10 -3 mg/kg-day |
| Dichlorvos | 62-73-7 | Oral | Plasma and RBC ChE inhibition in males and females brain ChE inhibition in males | RFD | 5 x 10 -4 mg/kg-day |
| Dichlorvos | 62-73-7 | Inhalation | Decreased brain cholinesterase activity | RFC | 5 x 10 -4 mg/m3 |
| Dimethoate | 60-51-5 | Oral | Brain ChE inhibition | RFD | 2 x 10 -4 mg/kg-day |
| 2,4-Dimethylphenol | 105-67-9 | Oral | Clinical signs (lethargy, prostration, and ataxia) and hematological changes | RFD | 2 x 10 -2 mg/kg-day |
| 2,4-Dinitrotoluene | 121-14-2 | Oral | Neurotoxicity, Heinz bodies and biliary tract hyperplasia | RFD | 2 x 10 -3 mg/kg-day |
| 1,4-Dioxane | 123-91-1 | Inhalation | Atrophy and respiratory metaplasia of the olfactory epithelium | RFC | 3 x 10 -2 mg/m3 |
| Disulfoton | 298-04-4 | Oral | ChE inhibition, optic nerve degeneration | RFD | 4 x 10 -5 mg/kg-day |
| 1,4-Dithiane | 505-29-3 | Oral | Nasal olfactory lesions | RFD | 1 x 10 -2 mg/kg-day |
| Endrin | 72-20-8 | Oral | Mild histological lesions in liver, occasional convulsions | RFD | 3 x 10 -4 mg/kg-day |
| Ethephon | 16672-87-0 | Oral | Plasma ChE inhibition | RFD | 5 x 10 -3 mg/kg-day |
| Ethion | 563-12-2 | Oral | Plasma cholinesterase inhibition | RFD | 5 x 10 -4 mg/kg-day |
| Ethyl p-nitrophenyl phenylphosphorothioate (EPN) | 2104-64-5 | Oral | Neurotoxicity | RFD | 1 x 10 -5 mg/kg-day |
| Fenamiphos | 22224-92-6 | Oral | ChE inhibition | RFD | 2.5 x 10 -4 mg/kg-day |
| Fonofos | 944-22-9 | Oral | Cholinesterase inhibition, cholinergic symptoms, and increased liver weight | RFD | 2 x 10 -3 mg/kg-day |
| 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) | 68631-49-2 | Oral | Neurobehavioral effects | RFD | 2 x 10 -4 mg/kg-day |
| Hexachloroethane | 67-72-1 | Inhalation | Neurotoxicity (tremors and ruffled pelt) | RFC | 3 x 10 -2 mg/m3 |
| Hexachlorophene | 70-30-4 | Oral | Swollen salivary glands, status spongiosis in brain and optic nerve | RFD | 3 x 10 -4 mg/kg-day |
| Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) | 121-82-4 | Oral | Convulsions in F344 rats | RFD | 4 x 10 -3 mg/kg-day |
| 1,6-Hexamethylene diisocyanate | 822-06-0 | Inhalation | Degeneration of olfactory epithelium | RFC | 1 x 10 -5 mg/m3 |
| n-Hexane | 110-54-3 | Inhalation | Peripheral neuropathy (decreased MCV at 12 weeks) | RFC | 7 x 10 -1 mg/m3 |
| 2-Hexanone | 591-78-6 | Inhalation | Motor conduction velocity of the sciatic-tibial nerve | RFC | 3 x 10 -2 mg/m3 |
| 2-Hexanone | 591-78-6 | Oral | Axonal swelling of the peripheral nerve | RFD | 5 x 10 -3 mg/kg-day |
| Hydrogen sulfide | 7783-06-4 | Inhalation | Nasal lesions of the olfactory mucosa | RFC | 2 x 10 -3 mg/m3 |
| Isobutyl alcohol | 78-83-1 | Oral | Hypoactivity and ataxia | RFD | 3 x 10 -1 mg/kg-day |
| Malathion | 121-75-5 | Oral | RBC ChE depression | RFD | 2 x 10 -2 mg/kg-day |
| Manganese | 7439-96-5 | Inhalation | Impairment of neurobehavioral function | RFC | 5 x 10 -5 mg/m3 |
| Manganese | 7439-96-5 | Oral | CNS effects | RFD | 1.4 x 10 -1 mg/kg-day |
| Mepiquat chloride | 24307-26-4 | Oral | Sedation and tonoclonic spasms decreased food intake and body weights hematologic effects | RFD | 3 x 10 -2 mg/kg-day |
| Mercury, elemental | 7439-97-6 | Inhalation | Hand tremor; increases in memory disturbances; slight subjective and objective evidence of autonomic dysfunction | RFC | 3 x 10 -4 mg/m3 |
| Merphos | 150-50-5 | Oral | Ataxia, delayed neurotoxicity and weight loss | RFD | 3 x 10 -5 mg/kg-day |
| Merphos oxide | 78-48-8 | Oral | Ataxia, delayed neurotoxicity and weight loss | RFD | 3 x 10 -5 mg/kg-day |
| Methamidophos | 10265-92-6 | Oral | ChE inhibition | RFD | 5 x 10 -5 mg/kg-day |
| Methanol | 67-56-1 | Inhalation | Reduced brain weight in rat pups at 6 weeks of age | RFC | 2 x 10 1 mg/m3 |
| Methyl chloride | 74-87-3 | Inhalation | Cerebellar lesions | RFC | 9 x 10 -2 mg/m3 |
| Methyl methacrylate | 80-62-6 | Inhalation | Degeneration/ atrophy of olfactory epithelium (male rats) | RFC | 7 x 10 -1 mg/m3 |
| Methyl parathion | 298-00-0 | Oral | RBC, ChE inhibition; reduced hemoglobin, hematocrit and RBCs | RFD | 2.5 x 10 -4 mg/kg-day |
| Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) | 101-68-8 | Inhalation | Hyperplasia of olfactory epithelium | RFC | 6 x 10 -4 mg/m3 |
| Methylmercury (MeHg) | 22967-92-6 | Oral | Developmental neuropsychological impairment | RFD | 1 x 10 -4 mg/kg-day |
| Methylmercury (MeHg) | 22967-92-6 | Oral | Developmental neuropsychological impairment | RFD | 1 x 10 -4 mg/kg-day |
| 2-Methylphenol | 95-48-7 | Oral | Decreased body weights and neurotoxicity | RFD | 5 x 10 -2 mg/kg-day |
| 3-Methylphenol | 108-39-4 | Oral | Decreased body weights and neurotoxicity | RFD | 5 x 10 -2 mg/kg-day |
| Naled | 300-76-5 | Oral | Brain ChE inhibition | RFD | 2 x 10 -3 mg/kg-day |
| Naphthalene | 91-20-3 | Inhalation | Nasal effects: hyperplasia and metaplasia in respiratory and olfactory epithelium, respectively | RFC | 3 x 10 -3 mg/m3 |
| Nitrobenzene | 98-95-3 | Inhalation | Bronchiolization of the alveoli and olfactory degeneration | RFC | 9 x 10 -3 mg/m3 |
| 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) | 60348-60-9 | Oral | Neurobehavioral effects | RFD | 1 x 10 -4 mg/kg-day |
| Phosmet | 732-11-6 | Oral | Reduced body weight (males), liver cell vacuolation, cholinesterase inhibition | RFD | 2 x 10 -2 mg/kg-day |
| Pirimiphos-methyl | 29232-93-7 | Oral | Transient plasma ChE depression | RFD | 1 x 10 -2 mg/kg-day |
| Propham | 122-42-9 | Oral | Increase in male spleen weight and ChE depression in females | RFD | 2 x 10 -2 mg/kg-day |
| Propionaldehyde | 123-38-6 | Inhalation | Atrophy of olfactory epithelium | RFC | 8 x 10 -3 mg/m3 |
| Propylene glycol monomethyl ether (PGME) | 107-98-2 | Inhalation | Mild reversible sedation | RFC | 2 mg/m3 |
| Pydrin | 51630-58-1 | Oral | Neurological dysfunction | RFD | 2.5 x 10 -2 mg/kg-day |
| Selenious acid | 7783-00-8 | Oral | Clinical selenosis | RFD | 5 x 10 -3 mg/kg-day |
| Selenium and Compounds | 7782-49-2 | Oral | Clinical selenosis | RFD | 5 x 10 -3 mg/kg-day |
| Silver cyanide | 506-64-9 | Oral | Weight loss, thyroid effects, and myelin degeneration | RFD | 1 x 10 -1 mg/kg-day |
| Styrene | 100-42-5 | Inhalation | CNS effects | RFC | 1 mg/m3 |
| 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) | 5436-43-1 | Oral | Neurobehavioral effects | RFD | 1 x 10 -4 mg/kg-day |
| Tetrachloroethylene (Perchloroethylene) | 127-18-4 | Oral | (See Note) | RFD | 6 x 10 -3 mg/kg-day |
| Tetrachloroethylene (Perchloroethylene) | 127-18-4 | Inhalation | (See Note) | RFC | 4 x 10 -2 mg/m3 |
| Tetrachlorovinphos | 961-11-5 | Oral | Reduced body weight gain, increased liver and kidney weights, and RBC ChE inhibition | RFD | 3 x 10 -2 mg/kg-day |
| Tetraethyldithiopyrophosphate | 3689-24-5 | Oral | Depressed RBC and plasma cholinesterase activity | RFD | 5 x 10 -4 mg/kg-day |
| Tetrahydrofuran | 109-99-9 | Inhalation | Increased liver weight and centrilobular cytomegaly, CNS effects (narcosis) | RFC | 2 mg/m3 |
| Thiram | 137-26-8 | Oral | Neurotoxicity | RFD | 5 x 10 -3 mg/kg-day |
| Toluene | 108-88-3 | Inhalation | Neurological effects in occupationally-exposed workers | RFC | 5 mg/m3 |
| 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) | 76-13-1 | Oral | Psychomotor impairment | RFD | 3 x 10 1 mg/kg-day |
| 1,1,1-Trichloroethane | 71-55-6 | Inhalation | Performance on neurobehavioral tests | RFC | 9 mg/m3 |
| 1,1,1-Trichloroethane | 71-55-6 | Inhalation | Performance on neurobehavioral tests | RFC | 7 mg/m3 |
| 1,1,1-Trichloroethane | 71-55-6 | Inhalation | Performance on neurobehavioral tests | RFC | 7 mg/m3 |
| 1,1,1-Trichloroethane | 71-55-6 | Inhalation | Performance on neurobehavioral tests | RFC | 6 mg/m3 |
| 1,1,1-Trichloroethane | 71-55-6 | Inhalation | Performance on neurobehavioral tests | RFC | 5 mg/m3 |
| 1,2,3-Trimethylbenzene | 526-73-8 | Inhalation | Decreased pain sensitivity in male Wistar rats | RFC | 2 x 10 -1 mg/m3 |
| 1,2,4-Trimethylbenzene | 95-63-6 | Oral | Decreased pain sensitivity in male Wistar rats | RFD | 1 x 10 -2 mg/kg-day |
| 1,2,4-Trimethylbenzene | 95-63-6 | Inhalation | Decreased pain sensitivity in male Wistar rats | RFC | 6 x 10 -2 mg/m3 |
| 1,2,4-Trimethylbenzene | 95-63-6 | Oral | Decreased pain sensitivity in male Wistar rats | RFD | 4 x 10 -2 mg/kg-day |
| 1,2,4-Trimethylbenzene | 95-63-6 | Inhalation | Decreased pain sensitivity in male Wistar rats | RFC | 2 x 10 -1 mg/m3 |
| 1,3,5-Trimethylbenzene | 108-67-8 | Inhalation | Decreased pain sensitivity in male Wistar rats | RFC | 2 x 10 -1 mg/m3 |
| 1,3,5-Trimethylbenzene | 108-67-8 | Oral | Decreased pain sensitivity in male Wistar rats | RFD | 1 x 10 -2 mg/kg-day |
| 1,2,3-Trimethylbenzene | 526-73-8 | Oral | Decreased pain sensitivity in male Wistar rats | RFD | 4 x 10 -2 mg/kg-day |
| 1,2,3-Trimethylbenzene | 526-73-8 | Inhalation | Decreased pain sensitivity in male Wistar rats | RFC | 6 x 10 -2 mg/m3 |
| 1,2,3-Trimethylbenzene | 526-73-8 | Oral | Decreased pain sensitivity in male Wistar rats | RFD | 1 x 10 -2 mg/kg-day |
| 1,3,5-Trimethylbenzene | 108-67-8 | Oral | Decreased pain sensitivity in male Wistar rats | RFD | 4 x 10 -2 mg/kg-day |
| 1,3,5-Trimethylbenzene | 108-67-8 | Inhalation | Decreased pain sensitivity in male Wistar rats | RFC | 6 x 10 -2 mg/m3 |
| Vinyl acetate | 108-05-4 | Inhalation | Nasal epithelial lesions | RFC | 2 x 10 -1 mg/m3 |
| Xylenes | 1330-20-7 | Inhalation | Impaired motor coordination (decreased rotarod performance) | RFC | 1 x 10 -1 mg/m3 |
| Zinc cyanide | 557-21-1 | Oral | Weight loss, thyroid effects, and myelin degeneration | RFD | 5 x 10 -2 mg/kg-day |
| n-Butanol | 71-36-3 | Oral | Hypoactivity and ataxia | RFD | 1 x 10 -1 mg/kg-day |